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nkat-1 kynurenine--oxoglutarate transaminase [ Caenorhabditis elegans ]

Gene ID: 185086, updated on 2-Nov-2024

Summary

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Official Symbol
nkat-1
Official Full Name
kynurenine--oxoglutarate transaminase
Primary source
WormBase:WBGene00009232
Locus tag
CELE_F28H6.3
See related
AllianceGenome:WB:WBGene00009232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable kynurenine-oxoglutarate transaminase activity. Predicted to be involved in L-kynurenine metabolic process and biosynthetic process. Predicted to be active in mitochondrion. Is expressed in RID; RMDVL; and RMDVR. Orthologous to several human genes including KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nkat-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (14137810..14140140, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene tRNA-His Neighboring gene Homeodomain-only protein Neighboring gene Serine/threonine-protein kinase akt-2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. Yu P, et al. Gene, 2006 Jan 3. PMID 16376499
  2. Bacterial diet affects the age-dependent decline of associative learning in Caenorhabditis elegans. Higurashi S, et al. Elife, 2023 May 30. PMID 37252859, Free PMC Article
  3. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Lemieux GA, et al. Cell, 2015 Jan 15. PMID 25594177, Free PMC Article
  4. FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans. Choi HS, et al. Nat Commun, 2023 Feb 2. PMID 36732543, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables kynurenine-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-kynurenine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kynurenine--oxoglutarate transaminase
NP_510355.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14137810..14140140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077954.4 → NP_510355.1  kynurenine--oxoglutarate transaminase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510355.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XX97
    Conserved Domains (1) summary
    COG0436
    Location:21 → 425
    AspB; Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]
Nucleotide Protein
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