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hlh-29 BHLH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 185136, updated on 2-Nov-2024

Summary

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Official Symbol
hlh-29
Official Full Name
BHLH domain-containing protein
Primary source
WormBase:WBGene00001968
Locus tag
CELE_F31A3.4
See related
AllianceGenome:WB:WBGene00001968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including E; Ea; amphid sheath cell; ganglia; and non-striated muscle. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hlh-29 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (17547492..17548639, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BHLH domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway. White A, et al. Biol Open, 2012 Mar 15. PMID 23213416, Free PMC Article
  2. Regulation of neuronal lineage decisions by the HES-related bHLH protein REF-1. Lanjuin A, et al. Dev Biol, 2006 Feb 1. PMID 16376329
  3. Molecular characterization of the Caenorhabditis elegans REF-1 family member, hlh-29/hlh-28. McMiller TL, et al. Biochim Biophys Acta, 2007 Jan. PMID 17258327
  4. H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity. Methot SP, et al. Nat Cell Biol, 2021 Nov. PMID 34737442, Free PMC Article
  5. The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways. Neves A, et al. Dev Cell, 2005 Jun. PMID 15935776

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BHLH domain-containing protein
NP_510837.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    17547492..17548639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078436.2 → NP_510837.1  BHLH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510837.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19917
    Conserved Domains (2) summary
    TIGR01612
    Location:35 → 136
    235kDa-fam; reticulocyte binding/rhoptry protein
    pfam00010
    Location:22 → 67
    HLH; Helix-loop-helix DNA-binding domain
Nucleotide Protein
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