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neg-1 Negative Effect on Gut development [ Caenorhabditis elegans ]

Gene ID: 185201, updated on 18-Sep-2024

Summary

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Official Symbol
neg-1
Official Full Name
Negative Effect on Gut development
Primary source
WormBase:WBGene00017985
Locus tag
CELE_F32D1.6
See related
AllianceGenome:WB:WBGene00017985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Located in nucleus. Is expressed in several structures, including AB; AB lineage cell; ABa; Psub1; and germ line. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See neg-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (4373754..4374874, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Activin_recp domain-containing protein Neighboring gene GMP reductase Neighboring gene Pre-mRNA polyadenylation factor Fip1 domain-containing protein Neighboring gene Protein lilliputian Neighboring gene BSD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Asymmetric transcript discovery by RNA-seq in C. elegans blastomeres identifies neg-1, a gene important for anterior morphogenesis. Osborne Nishimura E, et al. PLoS Genet, 2015 Apr. PMID 25875092, Free PMC Article
  2. POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA. Elewa A, et al. Dev Cell, 2015 Jul 6. PMID 26096734, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NEG-1 localizes in anterior nuclei, where it negatively regulates endo-mesoderm fates
    Title: POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Negative Effect on Gut development
NP_001256036.1
  • Product from WormBase gene class neg;
    Confirmed by transcript evidence
NP_001256037.1
  • Product from WormBase gene class neg;
    Confirmed by transcript evidence
NP_001317810.1
  • Product from WormBase gene class neg;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4373754..4374874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269108.3 → NP_001256037.1  Negative Effect on Gut development [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256037.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16292

  2. NM_001269107.2 → NP_001256036.1  Negative Effect on Gut development [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256036.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I2HA84

  3. NM_001330861.3 → NP_001317810.1  Negative Effect on Gut development [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A168H505
Nucleotide Protein
Heading Accession and Version

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