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npr-7 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 185321, updated on 2-Nov-2024

Summary

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Official Symbol
npr-7
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein
Primary source
WormBase:WBGene00018067
Locus tag
CELE_F35G8.1
See related
AllianceGenome:WB:WBGene00018067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable neuropeptide binding activity and neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Human ortholog(s) of this gene implicated in hypertension; lipid metabolism disorder; and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5) and PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See npr-7 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (9315436..9319180, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene TransThyretin-Related family domain Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Whole-genome analysis of 60 G protein-coupled receptors in Caenorhabditis elegans by gene knockout with RNAi. Keating CD, et al. Curr Biol, 2003 Sep 30. PMID 14521838
  2. Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. Styer KL, et al. Science, 2008 Oct 17. PMID 18801967, Free PMC Article
  3. A database of Caenorhabditis elegans behavioral phenotypes. Yemini E, et al. Nat Methods, 2013 Sep. PMID 23852451, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein
NP_509570.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9315436..9319180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077169.5 → NP_509570.3  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509570.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20067
    Conserved Domains (1) summary
    cd15203
    Location:25 → 317
    7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
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