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nprl-3 GATOR complex protein NPRL3 [ Caenorhabditis elegans ]

Gene ID: 185331, updated on 2-Nov-2024

Summary

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Official Symbol
nprl-3
Official Full Name
GATOR complex protein NPRL3
Primary source
WormBase:WBGene00018072
Locus tag
CELE_F35H10.7
See related
AllianceGenome:WB:WBGene00018072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in several processes, including TORC1 signaling; cellular response to amino acid starvation; and negative regulation of TORC1 signaling. Predicted to be located in lysosomal membrane. Predicted to be part of GATOR1 complex. Human ortholog(s) of this gene implicated in familial focal epilepsy with variable foci 3. Orthologous to human NPRL3 (NPR3 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nprl-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (8297492..8299843)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SLC41A/MgtE integral membrane domain-containing protein Neighboring gene Tubulin-specific chaperone E Neighboring gene Spindle and kinetochore-associated protein 2 Neighboring gene Centromere protein X

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans. Zhu H, et al. Genes Dev, 2015 Jun 15. PMID 26109047, Free PMC Article
  2. A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. Zhu H, et al. Elife, 2013 May 21. PMID 23705068, Free PMC Article
  3. Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction. Ryan KC, et al. Antioxidants (Basel), 2022 Aug 24. PMID 36139715, Free PMC Article
  4. Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism. Diot C, et al. Nat Commun, 2022 Sep 23. PMID 36151093, Free PMC Article
  5. Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1. Zhu M, et al. Dev Cell, 2021 Oct 11. PMID 34610328

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GATOR1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GATOR1 complex IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GATOR complex protein NPRL3
NP_001294069.1
  • Confirmed by transcript evidence
NP_501396.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8297492..8299843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068995.7 → NP_501396.1  GATOR complex protein NPRL3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501396.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20069
    Conserved Domains (1) summary
    cl24021
    Location:253 → 402
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

  2. NM_001307140.3 → NP_001294069.1  GATOR complex protein NPRL3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294069.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LXA9
    Conserved Domains (1) summary
    cl24021
    Location:234 → 385
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20069.1

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