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hrg-4 Heme transporter hrg-4 [ Caenorhabditis elegans ]

Gene ID: 185380, updated on 2-Nov-2024

Summary

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Official Symbol
hrg-4
Official Full Name
Heme transporter hrg-4
Primary source
WormBase:WBGene00009493
Locus tag
CELE_F36H1.5
See related
AllianceGenome:WB:WBGene00009493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables heme binding activity and heme transmembrane transporter activity. Involved in heme transport. Located in plasma membrane. Is expressed in intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hrg-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (11030143..11030993, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Heme transporter hrg-5 Neighboring gene ncRNA Neighboring gene Heme transporter hrg-6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lifespan regulation by targeting heme signaling in yeast. Patnaik PK, et al. Geroscience, 2024 Oct. PMID 38809391, Free PMC Article
  2. Long-term exposure to polystyrene nanoparticles at environmentally relevant concentration causes suppression in heme homeostasis signal associated with transgenerational toxicity induction in Caenorhabditis elegans. Liu H, et al. J Hazard Mater, 2023 Oct 5. PMID 37499489
  3. Haem transporter HRG-1 is essential in the barber's pole worm and an intervention target candidate. Yang Y, et al. PLoS Pathog, 2023 Jan. PMID 36716341, Free PMC Article
  4. Topologically conserved residues direct heme transport in HRG-1-related proteins. Yuan X, et al. J Biol Chem, 2012 Feb 10. PMID 22174408, Free PMC Article
  5. Iron acquisition and transcriptional regulation. Kaplan CD, et al. Chem Rev, 2009 Oct. PMID 19705827

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heme transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Heme transporter hrg-4
NP_001129857.1
  • Confirmed by transcript evidence
NP_001294019.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11030143..11030993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136385.2 → NP_001129857.1  Heme transporter hrg-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129857.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20106

  2. NM_001307090.4 → NP_001294019.1  Heme transporter hrg-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294019.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A061AD77, B3GWC4, Q20106
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20106.2

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