Pcolce procollagen C-endopeptidase enhancer protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcolceprovided by MGI
Official Full Name: procollagen C-endopeptidase enhancer proteinprovided by MGI
Primary source: MGI:MGI:105099
See related: Ensembl:ENSMUSG00000029718 AllianceGenome:MGI:105099
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P14; Astt2; Astt-2; PCPE-1
Summary: Predicted to enable collagen binding activity; heparin binding activity; and peptidase activator activity. Acts upstream of or within cellular response to leukemia inhibitory factor and proteolysis. Located in extracellular space. Is expressed in several structures, including adrenal gland; branchial arch; embryo endoderm; lower jaw; and umbilical blood vessel. Orthologous to human PCOLCE (procollagen C-endopeptidase enhancer). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 519.4), ovary adult (RPKM 131.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.59 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137603369..137609666, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137605105..137611522, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression.
Title: Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression.
Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice has No Major Impact on Cardiac Collagen and Function Under Basal Conditions.
Title: Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice has No Major Impact on Cardiac Collagen and Function Under Basal Conditions.
Bone morphogenetic protein-1/mTLD and PCPE-1 are upregulated in corneal scars. Both proteins may therefore contribute to the process of corneal scarring.
Title: Upregulation of bone morphogenetic protein-1/mammalian tolloid and procollagen C-proteinase enhancer-1 in corneal scarring.
procollagen C-proteinase enhancer-1 (PCPE-1) binds to heparin/heparan sulfate and has a role in interaction with cells
Title: Binding of procollagen C-proteinase enhancer-1 (PCPE-1) to heparin/heparan sulfate: properties and role in PCPE-1 interaction with cells.
PCOLCE1 is an important determinant of bone mechanical properties and geometry and of collagen fibril morphology in mammals.
Title: Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues.
PCPE1 and PCPE2 were found to be collagen-binding proteins, capable of binding at multiple sites on the triple helical portions of fibrillar collagens and also capable of competing for such binding with procollagen C-proteinases
Title: PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2120E (e-PCR)
- UniSTS:151127

RH98230 (e-PCR)
- UniSTS:84398

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	ISO Inferred from Sequence Orthology more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info	PubMed
enables peptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activator activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed

General protein information

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Preferred Names: procollagen C-endopeptidase enhancer 1

Names: astroglial cell transcript 2; procollagen C-proteinase enhancer 1; procollagen C-proteinase enhancer protein; procollagen COOH-terminal proteinase enhancer 1; type 1 procollagen C-proteinase enhancer protein; type I procollagen COOH-terminal proteinase enhancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008788.2 → NP_032814.2 procollagen C-endopeptidase enhancer 1 precursor

See identical proteins and their annotated locations for NP_032814.2

Status: VALIDATED

Source sequence(s)

AK144392, CX210896

Consensus CDS

CCDS39334.1

UniProtKB/Swiss-Prot

O35113, Q61398

UniProtKB/TrEMBL

Q3TX39, Q3UIP2

Related

ENSMUSP00000031731.8, ENSMUST00000031731.14

Conserved Domains (2) summary

cd00041
Location:36 → 146

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd03576
Location:334 → 460

NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...