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F39B2.5 SH2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 185487, updated on 2-Nov-2024

Summary

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Official Symbol
F39B2.5
Official Full Name
SH2 domain-containing protein
Primary source
WormBase:WBGene00009556
Locus tag
CELE_F39B2.5
See related
AllianceGenome:WB:WBGene00009556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable signaling adaptor activity. Predicted to be involved in intracellular signal transduction and negative regulation of signal transduction. Orthologous to human SOCS6 (suppressor of cytokine signaling 6) and SOCS7 (suppressor of cytokine signaling 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F39B2.5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (14775184..14776663, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 3 profile domain-containing protein Neighboring gene ncRNA Neighboring gene TrmE-type G domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 23 Neighboring gene Enoyl reductase (ER) domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH2 domain-containing protein
NP_493574.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    14775184..14776663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061173.5 → NP_493574.2  SH2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493574.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45498
    Conserved Domains (2) summary
    smart00253
    Location:126 → 169
    SOCS; suppressors of cytokine signalling
    cd10388
    Location:5 → 106
    SH2_SOCS7; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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