cyp-33E2 CYtochrome P450 family [Caenorhabditis elegans] - Gene

Summary

Official Symbol: cyp-33E2
Official Full Name: CYtochrome P450 family
Primary source: WormBase:WBGene00018334
Locus tag: CELE_F42A9.5
See related: AllianceGenome:WB:WBGene00018334
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables monooxygenase activity. Involved in long-chain fatty acid metabolic process and regulation of nematode pharyngeal pumping. Located in intracellular membrane-bounded organelle. Is expressed in pharynx. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Orthologous to human CYP2C8 (cytochrome P450 family 2 subfamily C member 8). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables steroid hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed

NP_501470.2

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The following sections contain reference sequences that belong to a specific genome build. Explain