srdf-2.2 3-oxo-5-alpha-steroid 4-dehydrogenase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: srdf-2.2
Official Full Name: 3-oxo-5-alpha-steroid 4-dehydrogenase
Primary source: WormBase:WBGene00009635
Locus tag: CELE_F42F12.3
See related: AllianceGenome:WB:WBGene00009635
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Involved in innate immune response. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hypospadias; prostate cancer; and prostatic hypertrophy. Orthologous to several human genes including SRD5A2 (steroid 5 alpha-reductase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables steroid dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in androgen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	HEP more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sex differentiation	IEA Inferred from Electronic Annotation more info
involved_in steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_510071.1

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