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sly-1 Sec1 family domain-containing protein 1 [ Caenorhabditis elegans ]

Gene ID: 185707, updated on 2-Nov-2024

Summary

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Official Symbol
sly-1
Official Full Name
Sec1 family domain-containing protein 1
Primary source
WormBase:WBGene00009654
Locus tag
CELE_F43D9.3
See related
AllianceGenome:WB:WBGene00009654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable syntaxin binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; intracellular protein transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be active in Golgi membrane. Orthologous to human SCFD1 (sec1 family domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sly-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
13
Sequence:
Chromosome: III; NC_003281.10 (10507058..10518596)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ubiquitin-related modifier 1 homolog Neighboring gene ncRNA Neighboring gene Stress-induced protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Sterile 20 Family Kinase and Its Co-factor CCM-3 Regulate Contractile Ring Proteins on Germline Intercellular Bridges. Rehain-Bell K, et al. Curr Biol, 2017 Mar 20. PMID 28285996, Free PMC Article
  2. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sec1 family domain-containing protein 1
NP_001122697.2
  • Confirmed by transcript evidence
NP_499317.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10507058..10518596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129225.4 → NP_001122697.2  Sec1 family domain-containing protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122697.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7LPF3
    Conserved Domains (1) summary
    cl15415
    Location:7 → 653
    Sec1; Sec1 family

  2. NM_066916.4 → NP_499317.2  Sec1 family domain-containing protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499317.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20364
    Conserved Domains (1) summary
    cl15415
    Location:7 → 650
    Sec1; Sec1 family
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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