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Pde1a phosphodiesterase 1A, calmodulin-dependent [ Mus musculus (house mouse) ]

Gene ID: 18573, updated on 2-Nov-2024

Summary

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Official Symbol
Pde1aprovided by MGI
Official Full Name
phosphodiesterase 1A, calmodulin-dependentprovided by MGI
Primary source
MGI:MGI:1201792
See related
Ensembl:ENSMUSG00000059173 AllianceGenome:MGI:1201792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in several processes, including cAMP-mediated signaling; cGMP catabolic process; and regulation of smooth muscle cell apoptotic process. Located in sperm flagellum. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE1A (phosphodiesterase 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 19.1), frontal lobe adult (RPKM 12.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Pde1a in Genome Data Viewer
Location:
2 C3; 2 47.64 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (79664797..80026862, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (79834453..80196522, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2625 Neighboring gene ITPR interacting domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_04937 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 1C Neighboring gene STARR-seq mESC enhancer starr_04938 Neighboring gene STARR-seq mESC enhancer starr_04939 Neighboring gene predicted gene, 54166 Neighboring gene STARR-seq mESC enhancer starr_04941 Neighboring gene STARR-seq mESC enhancer starr_04942 Neighboring gene STARR-seq mESC enhancer starr_04943 Neighboring gene predicted gene 13674 Neighboring gene STARR-positive B cell enhancer ABC_E5939 Neighboring gene predicted gene, 36153 Neighboring gene peroxiredoxin 6B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. Zhang H, et al. Sci Adv, 2019 May. PMID 31131329, Free PMC Article
  2. Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Miller CL, et al. Circ Res, 2009 Nov 6. PMID 19797176, Free PMC Article
  3. Generation and phenotypic characterization of Pde1a mutant mice. Wang X, et al. PLoS One, 2017. PMID 28750036, Free PMC Article
  4. Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm. Vasta V, et al. Biol Reprod, 2005 Oct. PMID 15901640
  5. Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival. Nagel DJ, et al. Circ Res, 2006 Mar 31. PMID 16514069, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDE1 inhibition induces PKA- and PKG-mediated promotion of proteasomal degradation of misfolded proteins and treats heart failure with preserved ejection fraction caused by CryAB(R120G) in a mouse model of cardiac proteinopathy
    Title: PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.
  2. These results support an important role of PDE1A in the renal pathogenesis of autosomal dominant polycystic kidney disease and in the regulation of blood pressure.
    Title: Generation and phenotypic characterization of Pde1a mutant mice.
  3. These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis
    Title: Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
  4. These results prove that the kinetic properties of PDE isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2+]i.
    Title: Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.
  5. a novel role for Ca(2+)/CaM-stimulated PDE1, particularly PDE1A, in regulating pathological cardiomyocyte hypertrophy via a cGMP/PKG-dependent mechanism, thereby demonstrating Ca(2+) and cGMP signaling cross-talk during cardiac hypertrophy.
    Title: Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.
  6. PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis.
    Title: Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.
  7. new variant PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function.
    Title: Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6)  1 citation
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC116577

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Names
61 kDa Cam-PDE
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
cam-PDE 1A
NP_001009978.1
NP_001009979.1
NP_001153054.1
NP_001342069.1
NP_001342070.1
NP_001342071.1
NP_001342073.1
NP_001407456.1
NP_001407458.1
NP_058024.2
XP_006498982.1
XP_030104296.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009978.2 → NP_001009978.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7

    See identical proteins and their annotated locations for NP_001009978.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' ends (UTR and coding sequence) compared to variant 1. The resulting isoform (7) has shorter and distinct N- and C-termini compared to isoform 2.
    Source sequence(s)
    AL928607
    Consensus CDS
    CCDS16173.1
    UniProtKB/TrEMBL
    F6X0V1
    Related
    ENSMUSP00000099712.4, ENSMUST00000102652.10
    Conserved Domains (2) summary
    pfam00233
    Location:150 → 366
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:9 → 65
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  2. NM_001009979.2 → NP_001009979.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9

    See identical proteins and their annotated locations for NP_001009979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' and 3' ends (UTR and coding sequence) compared to variant 1. The resulting isoform (9) has shorter and distinct N- and C-termini compared to isoform 2.
    Source sequence(s)
    AL928607
    Consensus CDS
    CCDS16174.1
    UniProtKB/TrEMBL
    F6X0V1
    Related
    ENSMUSP00000099711.4, ENSMUST00000102651.10
    Conserved Domains (2) summary
    pfam00233
    Location:150 → 366
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:9 → 65
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  3. NM_001159582.2 → NP_001153054.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

    See identical proteins and their annotated locations for NP_001153054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (2). Variants 1, 2, 10, and 11 all encode isoform 2.
    Source sequence(s)
    AL844577, AL928607, AL928811
    Consensus CDS
    CCDS16172.1
    UniProtKB/Swiss-Prot
    E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
    UniProtKB/TrEMBL
    F6X0V1
    Related
    ENSMUSP00000099713.2, ENSMUST00000102653.8
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  4. NM_001355140.2 → NP_001342069.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 2, and 11, encodes isoform 2.
    Source sequence(s)
    AL844577, AL928607, AL928811
    Consensus CDS
    CCDS16172.1
    UniProtKB/Swiss-Prot
    E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
    UniProtKB/TrEMBL
    F6X0V1
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  5. NM_001355141.2 → NP_001342070.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 2, and 10, encodes isoform 2.
    Source sequence(s)
    AL844577, AL928607, AL928811
    Consensus CDS
    CCDS16172.1
    UniProtKB/Swiss-Prot
    E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
    UniProtKB/TrEMBL
    F6X0V1
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  6. NM_001355142.2 → NP_001342071.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL844577, AL928607, AL928811
    UniProtKB/TrEMBL
    F6X0V1
    Related
    ENSMUSP00000160024.1, ENSMUST00000146076.9
    Conserved Domains (2) summary
    pfam00233
    Location:202 → 418
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:61 → 117
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  7. NM_001355144.2 → NP_001342073.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 13

    Status: VALIDATED

    Source sequence(s)
    AL928607
    Consensus CDS
    CCDS89501.1
    UniProtKB/TrEMBL
    A2ASF9, F6X0V1
    Related
    ENSMUSP00000088260.5, ENSMUST00000090756.11
    Conserved Domains (2) summary
    pfam00233
    Location:114 → 330
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:14 → 29
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  8. NM_001420527.1 → NP_001407456.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL928607, AL928811

  9. NM_001420529.1 → NP_001407458.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 14

    Status: VALIDATED

    Source sequence(s)
    AL928607, AL928811
    Related
    ENSMUSP00000120188.2, ENSMUST00000134739.2

  10. NM_016744.5 → NP_058024.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

    See identical proteins and their annotated locations for NP_058024.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 10, and 11 all encode isoform 2.
    Source sequence(s)
    AL844577, AL928607, AL928811
    Consensus CDS
    CCDS16172.1
    UniProtKB/Swiss-Prot
    E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
    UniProtKB/TrEMBL
    F6X0V1
    Related
    ENSMUSP00000099715.4, ENSMUST00000102655.10
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    79664797..80026862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498919.4 → XP_006498982.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1

    See identical proteins and their annotated locations for XP_006498982.1

    UniProtKB/Swiss-Prot
    E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
    UniProtKB/TrEMBL
    F6X0V1
    Conserved Domains (2) summary
    pfam00233
    Location:218 → 434
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:77 → 133
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  2. XM_030248436.2 → XP_030104296.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

    UniProtKB/TrEMBL
    F6X0V1
    Conserved Domains (2) summary
    pfam00233
    Location:202 → 418
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:61 → 117
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001355143.1: Suppressed sequence

    Description
    NM_001355143.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61481.3 GenPept UniProtKB/Swiss-Prot:Q61481

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