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cnep-1 CTD nuclear envelope phosphatase 1 homolog [ Caenorhabditis elegans ]

Gene ID: 185802, updated on 2-Nov-2024

Summary

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Official Symbol
cnep-1
Official Full Name
CTD nuclear envelope phosphatase 1 homolog
Primary source
WormBase:WBGene00018474
Locus tag
CELE_F45E12.1
See related
AllianceGenome:WB:WBGene00018474
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine phosphatase activity. Involved in nuclear membrane reassembly and regulation of nuclear division. Located in nuclear envelope. Is expressed in intestine and pharynx. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cnep-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (7310348..7313795)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Cullin-4 Neighboring gene B-related factor 1 Neighboring gene 60S ribosomal protein L23;Large ribosomal subunit protein uL14m Neighboring gene Neuropeptide-Like Protein Neighboring gene Uncharacterized protein Neighboring gene Amino acid transporter transmembrane domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatial regulation of phospholipid synthesis within the nuclear envelope domain of the endoplasmic reticulum. Bahmanyar S. Nucleus, 2015. PMID 25671705, Free PMC Article
  2. Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure. Penfield L, et al. J Cell Biol, 2020 May 4. PMID 32271860, Free PMC Article
  3. Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. Siniossoglou S, et al. J Biol Chem, 2000 Jun 23. PMID 10777497
  4. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Bahmanyar S, et al. Genes Dev, 2014 Jan 15. PMID 24449268, Free PMC Article
  5. A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans. Qadota H, et al. Mol Biol Cell, 2008 Jun. PMID 18337465, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in nuclear envelope organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear membrane reassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Nem1-Spo7 phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CTD nuclear envelope phosphatase 1 homolog
NP_001254123.1
  • Confirmed by transcript evidence
NP_001379752.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7310348..7313795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393116.1 → NP_001379752.1  CTD nuclear envelope phosphatase 1 homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H1ZUW4, Q20432
    Conserved Domains (1) summary
    TIGR02251
    Location:57 → 225
    HIF-SF_euk; Dullard-like phosphatase domain

  2. NM_001267194.3 → NP_001254123.1  CTD nuclear envelope phosphatase 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254123.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20432
    Conserved Domains (1) summary
    TIGR02251
    Location:87 → 255
    HIF-SF_euk; Dullard-like phosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20432.1

Gene LinkOut

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