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bli-5 Kunitz-type protein bli-5 [ Caenorhabditis elegans ]

Gene ID: 185812, updated on 2-Nov-2024

Summary

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Official Symbol
bli-5
Official Full Name
Kunitz-type protein bli-5
Primary source
WormBase:WBGene00000255
Locus tag
CELE_F45G2.5
See related
AllianceGenome:WB:WBGene00000255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables serine-type endopeptidase activity. A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle; protein catabolic process; and vulval development. Is expressed in excretory cell; excretory duct; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See bli-5 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (13427640..13429768, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Myosin motor domain-containing protein;Myosin_tail_1 domain-containing protein Neighboring gene ncRNA Neighboring gene Exonuclease 1 Neighboring gene Coatomer subunit epsilon Neighboring gene TNF Receptor Associated Factor (TRAF) homolog Neighboring gene COMM domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes. Stepek G, et al. Mol Biochem Parasitol, 2010 Jan. PMID 19716386
  2. Biosynthesis and enzymology of the Caenorhabditis elegans cuticle: identification and characterization of a novel serine protease inhibitor. Page AP, et al. Int J Parasitol, 2006 May 31. PMID 16500660
  3. Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans. Ch'ng Q, et al. Genetics, 2003 Aug. PMID 12930745, Free PMC Article
  4. Most ultraviolet irradiation induced mutations in the nematode Caenorhabditis elegans are chromosomal rearrangements. Stewart HI, et al. Mutat Res, 1991 Jul. PMID 2067542
  5. The genetic analysis of a reciprocal translocation, eT1(III; V), in Caenorhabditis elegans. Rosenbluth RE, et al. Genetics, 1981 Nov-Dec. PMID 6953041, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BLI-5 plays a functionally conserved role in cuticle formation in a C. elegans and nematodes.
    Title: The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of collagen and cuticulin-based cuticle IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Kunitz-type protein bli-5
NP_499772.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13427640..13429768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067371.3 → NP_499772.1  Kunitz-type protein bli-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499772.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62247
    Conserved Domains (1) summary
    cl00101
    Location:134 → 184
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62247.1

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