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Pde7a phosphodiesterase 7A [ Mus musculus (house mouse) ]

Gene ID: 18583, updated on 2-Nov-2024

Summary

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Official Symbol
Pde7aprovided by MGI
Official Full Name
phosphodiesterase 7Aprovided by MGI
Primary source
MGI:MGI:1202402
See related
Ensembl:ENSMUSG00000069094 AllianceGenome:MGI:1202402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in cAMP-mediated signaling. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human PDE7A (phosphodiesterase 7A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 11.8), whole brain E14.5 (RPKM 10.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Pde7a in Genome Data Viewer
Location:
3 A2; 3 5.36 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (19277272..19365486, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19223108..19311322, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E334 Neighboring gene STARR-positive B cell enhancer ABC_E3427 Neighboring gene mitochondrial fission regulator 1 Neighboring gene STARR-seq mESC enhancer starr_07090 Neighboring gene STARR-seq mESC enhancer starr_07091 Neighboring gene RIKEN cDNA 3110037C07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:19250042-19250343 Neighboring gene predicted gene, 52602 Neighboring gene predicted gene, 42188

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuronal lack of PDE7a disrupted working memory, spatial learning, and memory but facilitated cued fear memory in mice. Liu Z, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2023 Jan 10. PMID 36220621
  2. Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells. Goto M, et al. Cell Immunol, 2009. PMID 19477436
  3. ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-alpha level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation model in mice. Kadoshima-Yamaoka K, et al. Eur J Pharmacol, 2009 Jun 24. PMID 19379723
  4. Cloning, characterization, and tissue distribution of mouse phosphodiesterase 7A1. Wang P, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027622
  5. Phosphodiesterase 7A-deficient mice have functional T cells. Yang G, et al. J Immunol, 2003 Dec 15. PMID 14662840

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice.
    Title: Upregulation of Phosphodiesterase 7A Contributes to Concurrent Pain and Depression via Inhibition of cAMP-PKA-CREB-BDNF Signaling and Neuroinflammation in the Hippocampus of Mice.
  2. Neuronal lack of PDE7a disrupted working memory, spatial learning, and memory but facilitated cued fear memory in mice.
    Title: Neuronal lack of PDE7a disrupted working memory, spatial learning, and memory but facilitated cued fear memory in mice.
  3. PDE7 has roles in regulating oligodendrocyte precursor survival and differentiation during brain development and in adulthood
    Title: Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival.
  4. PDE7A is involved in regulation of cell proliferation and cytokine production of NKT cells.
    Title: Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells.
  5. results demonstrate that PDE7A might regulate TNF-alpha production in keratinocytes in a cAMP-dependent fashion
    Title: ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-alpha level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation model in mice.
  6. PDE7A is not essential for activation of T lymphocytes; its inactivation by targeted gene disruption appears to enhance in vivo humoral immune responses.
    Title: Phosphodiesterase 7A-deficient mice have functional T cells.
  7. The roles PDE7A1 and its regulatory region play in cAMP signaling were examined by studying interactions with PKA subunits.
    Title: PDE7A1, a cAMP-specific phosphodiesterase, inhibits cAMP-dependent protein kinase by a direct interaction with C.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
high affinity 3',5'-cyclic-AMP phosphodiesterase 7A
Names
cAMP-specific phosphodiesterase 7A
high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
NP_001116231.1
NP_032828.2
XP_006535468.1
XP_006535469.1
XP_006535471.1
XP_030108316.1
XP_036018817.1
XP_036018818.1
XP_036018819.1
XP_036018820.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122759.3 → NP_001116231.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102756, AC127283
    Consensus CDS
    CCDS50871.1
    UniProtKB/TrEMBL
    Q3U3Y7, Q6P5G2
    Related
    ENSMUSP00000096800.4, ENSMUST00000099195.10
    Conserved Domains (2) summary
    pfam00233
    Location:211 → 431
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam09195
    Location:51 → 128
    Endonuc-BglII; Restriction endonuclease BglII

  2. NM_001428503.1 → NP_001415432.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102756, AC127283

  3. NM_008802.4 → NP_032828.2  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127283
    Consensus CDS
    CCDS38398.1
    UniProtKB/Swiss-Prot
    P70453, Q3TFY5, Q9ERB3
    UniProtKB/TrEMBL
    Q6P5G2
    Related
    ENSMUSP00000088863.5, ENSMUST00000091314.11
    Conserved Domains (2) summary
    pfam00233
    Location:185 → 405
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam09195
    Location:16 → 102
    Endonuc-BglII; Restriction endonuclease BglII

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    19277272..19365486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162924.1 → XP_036018817.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X3

    Conserved Domains (1) summary
    pfam00233
    Location:65 → 285
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  2. XM_036162925.1 → XP_036018818.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X3

    Conserved Domains (1) summary
    pfam00233
    Location:65 → 285
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. XM_006535405.4 → XP_006535468.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X1

    UniProtKB/TrEMBL
    Q6P5G2
    Conserved Domains (1) summary
    pfam00233
    Location:206 → 426
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. XM_006535408.5 → XP_006535471.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X4

    Conserved Domains (1) summary
    pfam00233
    Location:21 → 241
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. XM_036162926.1 → XP_036018819.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X3

    Conserved Domains (1) summary
    pfam00233
    Location:65 → 285
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  6. XM_036162927.1 → XP_036018820.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X4

    Conserved Domains (1) summary
    pfam00233
    Location:21 → 241
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  7. XM_030252456.2 → XP_030108316.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X4

    Conserved Domains (1) summary
    pfam00233
    Location:21 → 241
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  8. XM_006535406.5 → XP_006535469.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform X2

    Conserved Domains (1) summary
    pfam00233
    Location:183 → 403
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RNA

  1. XR_004941293.1 RNA Sequence

  2. XR_389588.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70453.2 GenPept UniProtKB/Swiss-Prot:P70453

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