U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pde8a phosphodiesterase 8A [ Mus musculus (house mouse) ]

Gene ID: 18584, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Pde8aprovided by MGI
Official Full Name
phosphodiesterase 8Aprovided by MGI
Primary source
MGI:MGI:1277116
See related
Ensembl:ENSMUSG00000025584 AllianceGenome:MGI:1277116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pde8
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in cellular response to epidermal growth factor stimulus and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; gut gland; integumental system; nervous system; and skeleton. Orthologous to human PDE8A (phosphodiesterase 8A). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in testis adult (RPKM 48.2), kidney adult (RPKM 13.7) and 18 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pde8a in Genome Data Viewer
Location:
7 D3; 7 45.71 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80863013..80984283)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81213265..81334535)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6B Neighboring gene STARR-seq mESC enhancer starr_19358 Neighboring gene predicted gene 44968 Neighboring gene translocase of inner mitochondrial membrane 17a pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88496762-88496958 Neighboring gene ribosomal protein S17 Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12) pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer's Disease. Qiu NZ, et al. Neurochem Res, 2024 Aug. PMID 38782837
  2. Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes. Dong H, et al. Biochem Biophys Res Commun, 2006 Jun 30. PMID 16696947
  3. Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A. Vasta V, et al. Proc Natl Acad Sci U S A, 2006 Dec 26. PMID 17172443, Free PMC Article
  4. Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes. Patrucco E, et al. J Mol Cell Cardiol, 2010 Aug. PMID 20353794, Free PMC Article
  5. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Soderling SH, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671792, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer's Disease.
    Title: Phosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer's Disease.
  2. AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.
    Title: AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.
  3. our studies demonstrate that PDE8A inhibition by enzymatic inhibitors or PDE8A-Raf-1 kinase complex disruptors decreases Teff cell adhesion and migration under flow, and represents a novel approach to target T cells in inflammation
    Title: PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex.
  4. findings suggest that both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping CEH/HSL inactive and StAR protein expression low
    Title: cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.
  5. PDE8 as a novel target for suppression of Teff cell functions, including adhesion to endothelial cells
    Title: PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER.
  6. PDE8A plays a critical role in the modulation of at least one compartment of cAMP and hence PKA activity during beta-adrenergic receptor (betaAR) activation in ventricular myocytes.
    Title: Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes.
  7. pharmacological manipulation of PDE8A, alone or in combination with other PDEs present in Leydig cells, may be exploited to modulate testosterone synthesis
    Title: Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to epidermal growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
NP_032829.1
XP_036008663.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008803.3 → NP_032829.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

    See identical proteins and their annotated locations for NP_032829.1

    Status: VALIDATED

    Source sequence(s)
    AF067806, AK148238, AV272936, BC125578, CO808457
    Consensus CDS
    CCDS40005.1
    UniProtKB/Swiss-Prot
    O88502, Q059P6
    UniProtKB/TrEMBL
    Q3UFX9
    Related
    ENSMUSP00000026672.8, ENSMUST00000026672.8
    Conserved Domains (5) summary
    COG0745
    Location:78 → 155
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    cd00130
    Location:226 → 320
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:550 → 801
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:222 → 320
    PAS_9; PAS domain
    cl19078
    Location:79 → 165
    REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80863013..80984283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152770.1 → XP_036008663.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    Conserved Domains (4) summary
    COG0745
    Location:78 → 155
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    COG2202
    Location:118 → 320
    PAS; PAS domain [Signal transduction mechanisms]
    pfam13426
    Location:222 → 320
    PAS_9; PAS domain
    cl21469
    Location:550 → 574
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88502.1 GenPept UniProtKB/Swiss-Prot:O88502

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous