F49H6.5 GTP 3',8-cyclase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F49H6.5
Official Full Name: GTP 3',8-cyclase
Primary source: WormBase:WBGene00009908
Locus tag: CELE_F49H6.5
See related: AllianceGenome:WB:WBGene00009908
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be part of molybdopterin synthase complex. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F49H6.5 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (17023241..17025527)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F49H6.5 (e-PCR)
- UniSTS:307086

F49H6.8 (e-PCR)
- UniSTS:320984

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables GTP 3',8'-cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTP 3',8'-cyclase activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cyclic pyranopterin monophosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in Mo-molybdopterin cofactor biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of molybdopterin synthase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTP 3',8-cyclase

NP_001368565.1

Confirmed by transcript evidence

NP_001370025.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

17023241..17025527

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383480.1 → NP_001370025.1 GTP 3',8-cyclase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9XV04

Conserved Domains (1) summary

PLN02951
Location:67 → 389

PLN02951; Molybderin biosynthesis protein CNX2
NM_001380850.1 → NP_001368565.1 GTP 3',8-cyclase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AVJ9

Conserved Domains (1) summary

PLN02951
Location:2 → 322

PLN02951; Molybderin biosynthesis protein CNX2