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frm-3 FERM domain-containing protein;FYVE, RhoGEF and PH domain-containing protein 6;Moesin/ezrin/radixin homolog 1 [ Caenorhabditis elegans ]

Gene ID: 186110, updated on 2-Nov-2024

Summary

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Official Symbol
frm-3
Official Full Name
FERM domain-containing protein;FYVE, RhoGEF and PH domain-containing protein 6;Moesin/ezrin/radixin homolog 1
Primary source
WormBase:WBGene00001490
Locus tag
CELE_H05G16.1
See related
AllianceGenome:WB:WBGene00001490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GABA receptor binding activity. Involved in gamma-aminobutyric acid receptor clustering. Predicted to be located in adherens junction and plasma membrane. Is expressed in body wall musculature and dorsal nerve cord. Human ortholog(s) of this gene implicated in congenital nystagmus 1. Orthologous to several human genes including FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See frm-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
20
Sequence:
Chromosome: X; NC_003284.9 (11572505..11585126)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Bicarbonate transporter-like transmembrane domain-containing protein Neighboring gene PID domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission. Li L, et al. PLoS Genet, 2022 Oct. PMID 36279278, Free PMC Article
  2. FRMD7 Mutations Disrupt the Interaction with GABRA2 and May Result in Infantile Nystagmus Syndrome. Jiang L, et al. Invest Ophthalmol Vis Sci, 2020 May 11. PMID 32446246, Free PMC Article
  3. The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABA(A) receptors. Zhou X, et al. Nat Commun, 2020 May 29. PMID 32471987, Free PMC Article
  4. A network of autism linked genes stabilizes two pools of synaptic GABA(A) receptors. Tong XJ, et al. Elife, 2015 Nov 17. PMID 26575289, Free PMC Article
  5. UNC-43/CaMKII-triggered anterograde signals recruit GABA(A)Rs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs. Hao Y, et al. Nat Commun, 2023 Mar 15. PMID 36918518, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GABA receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in gamma-aminobutyric acid receptor clustering IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in gamma-aminobutyric acid receptor clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FERM domain-containing protein;FYVE, RhoGEF and PH domain-containing protein 6;Moesin/ezrin/radixin homolog 1
NP_001338849.1
  • Confirmed by transcript evidence
NP_001361874.1
  • Confirmed by transcript evidence
NP_509935.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11572505..11585126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351892.5 → NP_001338849.1  Moesin/ezrin/radixin homolog 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1X7RBN3
    Conserved Domains (6) summary
    smart00295
    Location:38 → 231
    B41; Band 4.1 homologues
    cd13193
    Location:218 → 339
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    cd13235
    Location:954 → 1052
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    pfam08736
    Location:332 → 365
    FA; FERM adjacent (FA)
    cl02571
    Location:583 → 710
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:790 → 896
    PH-like; Pleckstrin homology-like domain

  2. NM_001375142.3 → NP_001361874.1  FERM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17905
    Conserved Domains (3) summary
    smart00295
    Location:26 → 219
    B41; Band 4.1 homologues
    cd13193
    Location:206 → 327
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    pfam08736
    Location:320 → 353
    FA; FERM adjacent (FA)

  3. NM_077534.3 → NP_509935.2  FYVE, RhoGEF and PH domain-containing protein 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509935.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDC0
    Conserved Domains (3) summary
    cd13235
    Location:536 → 634
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    cl02571
    Location:165 → 292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:372 → 478
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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