hsp-17 SHSP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hsp-17
Official Full Name: SHSP domain-containing protein
Primary source: WormBase:WBGene00002021
Locus tag: CELE_F52E1.7
See related: AllianceGenome:WB:WBGene00002021
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein refolding and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in excretory cell. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to human CRYAA (crystallin alpha A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hsp-17 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (8384799..8385929, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The permanently chaperone-active small heat shock protein Hsp17 from Caenorhabditis elegans exhibits topological separation of its N-terminal regions.
Title: The permanently chaperone-active small heat shock protein Hsp17 from Caenorhabditis elegans exhibits topological separation of its N-terminal regions.
The noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase.
Title: The noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase.
This study reports that the heterologous expression of HSP17, enables E. coli cells to grow at 50 degrees C, which is their highest growth temperature ever reported.
Title: A small heat shock protein enables Escherichia coli to grow at a lethal temperature of 50°C conceivably by maintaining cell envelope integrity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F52E1.7 (e-PCR)
- UniSTS:315879

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SHSP domain-containing protein

NP_001023957.1

Partially confirmed by transcript evidence

NP_001023958.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

8384799..8385929 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028787.7 → NP_001023958.1 SHSP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023958.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JP52

Conserved Domains (1) summary

cd06526
Location:48 → 127

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
NM_001028786.8 → NP_001023957.1 SHSP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023957.1

Status: REVIEWED

UniProtKB/TrEMBL

Q20660

Conserved Domains (1) summary

cd06526
Location:49 → 128

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...