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duox-2 NAD(P)H oxidase (H2O2-forming) [ Caenorhabditis elegans ]

Gene ID: 186188, updated on 2-Nov-2024

Summary

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Official Symbol
duox-2
Official Full Name
NAD(P)H oxidase (H2O2-forming)
Primary source
WormBase:WBGene00018771
Locus tag
CELE_F53G12.3
See related
AllianceGenome:WB:WBGene00018771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable superoxide-generating NAD(P)H oxidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Predicted to be located in membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to several human genes including DUOX2 (dual oxidase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See duox-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
21
Sequence:
Chromosome: I; NC_003279.8 (137845..144565)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Growth-regulating factor;K Homology domain-containing protein Neighboring gene LisH domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene Dual oxidase 1 Neighboring gene SSD domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox. Edens WA, et al. J Cell Biol, 2001 Aug 20. PMID 11514595, Free PMC Article
  2. ROS regulation of RAS and vulva development in Caenorhabditis elegans. Kramer-Drauberg M, et al. PLoS Genet, 2020 Jun. PMID 32544191, Free PMC Article
  3. Redox Signaling of NADPH Oxidases Regulates Oxidative Stress Responses, Immunity and Aging. Ewald CY. Antioxidants (Basel), 2018 Sep 28. PMID 30274229, Free PMC Article
  4. Caenorhabditis elegans exoskeleton collagen COL-19: an adult-specific marker for collagen modification and assembly, and the analysis of organismal morphology. Thein MC, et al. Dev Dyn, 2003 Mar. PMID 12619137
  5. The Redox System in C. elegans, a Phylogenetic Approach. Johnston AD, et al. J Toxicol, 2012. PMID 22899914, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NAD(P)H oxidase H2O2-forming activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables superoxide-generating NAD(P)H oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NAD(P)H oxidase (H2O2-forming)
NP_490684.1
  • Predicted

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    137845..144565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058283.1 → NP_490684.1  NAD(P)H oxidase (H2O2-forming) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490684.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01795
    Conserved Domains (5) summary
    cd06186
    Location:1224 → 1408
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:41 → 596
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    COG5126
    Location:792 → 895
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam01794
    Location:1041 → 1182
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03098
    Location:39 → 552
    An_peroxidase; Animal haem peroxidase
Nucleotide Protein
Heading Accession and Version

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