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F54C9.11 GDP/GTP exchange factor Sec2 N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186226, updated on 2-Nov-2024

Summary

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Official Symbol
F54C9.11
Official Full Name
GDP/GTP exchange factor Sec2 N-terminal domain-containing protein
Primary source
WormBase:WBGene00010045
Locus tag
CELE_F54C9.11
See related
AllianceGenome:WB:WBGene00010045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in exocytosis. Predicted to be active in Golgi to plasma membrane transport vesicle. Is expressed in hypodermis; vulA; vulB1; vulB2; and vulval muscle. Orthologous to human RAB3IP (RAB3A interacting protein) and RAB3IL1 (RAB3A interacting protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F54C9.11 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (8583034..8585086, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Pumilio domain-containing protein 5 Neighboring gene Protein KRI1 homolog Neighboring gene ADP-ribosylation factor-like protein 1 Neighboring gene Transcription factor aptf-4 Neighboring gene Transcription factor AP-2 C-terminal domain-containing protein Neighboring gene GPI ethanolamine phosphate transferase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi to plasma membrane transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GDP/GTP exchange factor Sec2 N-terminal domain-containing protein
NP_495817.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8583034..8585086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063416.5 → NP_495817.3  GDP/GTP exchange factor Sec2 N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495817.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20759
    Conserved Domains (1) summary
    pfam06428
    Location:61 → 133
    Sec2p; GDP/GTP exchange factor Sec2p
Nucleotide Protein
Heading Accession and Version

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