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cah-1 Alpha-carbonic anhydrase domain-containing protein;Putative carbonic anhydrase-like protein 1 [ Caenorhabditis elegans ]

Gene ID: 186231, updated on 2-Nov-2024

Summary

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Official Symbol
cah-1
Official Full Name
Alpha-carbonic anhydrase domain-containing protein;Putative carbonic anhydrase-like protein 1
Primary source
WormBase:WBGene00000279
Locus tag
CELE_F54D8.4
See related
AllianceGenome:WB:WBGene00000279
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydro-lyase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be located in extracellular region. Is expressed in head ganglion; neurons; and ventral nerve cord. Orthologous to human CA10 (carbonic anhydrase 10) and CA11 (carbonic anhydrase 11). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cah-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (5083206..5085629, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cytochrome c oxidase subunit 6A, mitochondrial Neighboring gene ncRNA Neighboring gene FIP (Fungus-Induced Protein) Related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a nuclear carbonic anhydrase in Caenorhabditis elegans. Sherman TA, et al. Biochim Biophys Acta, 2012 Apr. PMID 22245567, Free PMC Article
  2. Molecular and biochemical analysis of the α class carbonic anhydrases in Caenorhabditis elegans. Fasseas MK, et al. Mol Biol Rep, 2011 Mar. PMID 20842438
  3. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydro-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Alpha-carbonic anhydrase domain-containing protein;Putative carbonic anhydrase-like protein 1
NP_001309492.1
  • Partially confirmed by transcript evidence
NP_001309597.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5083206..5085629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322586.2 → NP_001309492.1  Putative carbonic anhydrase-like protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20781
    Conserved Domains (1) summary
    cd03121
    Location:39 → 295
    alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

  2. NM_001322587.1 → NP_001309597.1  Alpha-carbonic anhydrase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MB23
    Conserved Domains (1) summary
    cl00012
    Location:1 → 201
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
Nucleotide Protein
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