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dgk-3 putative diacylglycerol kinase 3 [ Caenorhabditis elegans ]

Gene ID: 186262, updated on 2-Nov-2024

Summary

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Official Symbol
dgk-3
Official Full Name
putative diacylglycerol kinase 3
Primary source
WormBase:WBGene00000960
Locus tag
CELE_F54G8.2
See related
AllianceGenome:WB:WBGene00000960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP-dependent diacylglycerol kinase activity. Involved in olfactory behavior; regulation of long-term neuronal synaptic plasticity; and thermotaxis. Predicted to be active in plasma membrane. Is expressed in head; intestine; nervous system; and pharyngeal lumen. Orthologous to human DGKA (diacylglycerol kinase alpha); DGKB (diacylglycerol kinase beta); and DGKG (diacylglycerol kinase gamma). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dgk-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
15
Sequence:
Chromosome: III; NC_003281.10 (9163068..9168196)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Patched-related protein 9 Neighboring gene ncRNA Neighboring gene Integrin alpha ina-1 Neighboring gene pseudo Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans. Biron D, et al. Nat Neurosci, 2006 Dec. PMID 17086178
  2. BRCA1-BARD1 Regulates Axon Regeneration in Concert with the Gqα-DAG Signaling Network. Sakai Y, et al. J Neurosci, 2021 Mar 31. PMID 33593852, Free PMC Article
  3. PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion. Edwards MR, et al. J Neurosci, 2012 May 16. PMID 22593072, Free PMC Article
  4. Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans. Matsuki M, et al. Proc Natl Acad Sci U S A, 2006 Jan 24. PMID 16418272, Free PMC Article
  5. Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma. Espelt MV, et al. J Gen Physiol, 2005 Oct. PMID 16186564, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in olfactory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in thermotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative diacylglycerol kinase 3
NP_499031.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9163068..9168196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066630.4 → NP_499031.3  putative diacylglycerol kinase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499031.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q03603
    Conserved Domains (7) summary
    smart00045
    Location:578 → 753
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:429 → 551
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:429 → 763
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00051
    Location:174 → 243
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:266 → 317
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:178 → 239
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:3 → 168
    DAG_kinase_N; Diacylglycerol kinase N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03603.3

Gene LinkOut

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