F57B9.3 RNA helicase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: F57B9.3
Official Full Name: RNA helicase
Primary source: WormBase:WBGene00018997
Locus tag: CELE_F57B9.3
See related: AllianceGenome:WB:WBGene00018997
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable translation initiation factor activity. Involved in translation. Predicted to be located in P granule. Predicted to be active in cytoplasmic stress granule. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in PERK-mediated unfolded protein response	HEP more info	PubMed
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P granule	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info

NP_498514.2

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The following sections contain reference sequences that belong to a specific genome build. Explain