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glo-2 Biogenesis of lysosome-related organelles complex 1 subunit 6;Biogenesis of lysosome-related organelles complex 1 subunit 7 [ Caenorhabditis elegans ]

Gene ID: 186447, updated on 2-Nov-2024

Summary

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Official Symbol
glo-2
Official Full Name
Biogenesis of lysosome-related organelles complex 1 subunit 6;Biogenesis of lysosome-related organelles complex 1 subunit 7
Primary source
WormBase:WBGene00019010
Locus tag
CELE_F57C9.3
See related
AllianceGenome:WB:WBGene00019010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein homodimerization activity. Involved in endosomal transport and positive regulation of intracellular protein transport. Located in endosome. Is expressed in intestine and seam cell. Used to study Hermansky-Pudlak syndrome. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See glo-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (4836187..4844966)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene HORMA domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene C-type LECtin Neighboring gene Putative pyridoxal kinase;pyridoxal kinase Neighboring gene Rho-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neural Glyoxalase Pathway Enhancement by Morin Derivatives in an Alzheimer's Disease Model. Frandsen J, et al. ACS Chem Neurosci, 2020 Feb 5. PMID 31909963
  2. C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules. Hermann GJ, et al. PLoS One, 2012. PMID 22916203, Free PMC Article
  3. Asymmetric organelle positioning during epithelial polarization of C. elegans intestinal cells. Brandt JN, et al. Dev Biol, 2022 Jan. PMID 34597675, Free PMC Article
  4. A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes. Fazeli G, et al. Curr Biol, 2023 Feb 27. PMID 36652947, Free PMC Article
  5. Genetic analysis of lysosomal trafficking in Caenorhabditis elegans. Hermann GJ, et al. Mol Biol Cell, 2005 Jul. PMID 15843430, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in endosomal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of BLOC-1 complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Biogenesis of lysosome-related organelles complex 1 subunit 6;Biogenesis of lysosome-related organelles complex 1 subunit 7
NP_001293460.1
  • Confirmed by transcript evidence
NP_491461.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4836187..4844966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306531.4 → NP_001293460.1  Biogenesis of lysosome-related organelles complex 1 subunit 7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293460.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    J7JQW0, O01822
    UniProtKB/TrEMBL
    M1ZK00

  2. NM_059060.3 → NP_491461.3  Biogenesis of lysosome-related organelles complex 1 subunit 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491461.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01822
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01822.5

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