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lys-5 Lysozyme-like protein 5 [ Caenorhabditis elegans ]

Gene ID: 186491, updated on 2-Nov-2024

Summary

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Official Symbol
lys-5
Official Full Name
Lysozyme-like protein 5
Primary source
WormBase:WBGene00003094
Locus tag
CELE_F58B3.2
See related
AllianceGenome:WB:WBGene00003094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lysozyme activity. Involved in defense response to Gram-positive bacterium. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lys-5 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_003282.8 (11624252..11625582, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Delta-like protein Neighboring gene LYSozyme Neighboring gene ncRNA Neighboring gene LYSozyme Neighboring gene NUC153 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Decrease of Staphylococcus aureus Virulence by Helcococcus kunzii in a Caenorhabditis elegans Model. Ngba Essebe C, et al. Front Cell Infect Microbiol, 2017. PMID 28361041, Free PMC Article
  2. Protist-type lysozymes of the nematode Caenorhabditis elegans contribute to resistance against pathogenic Bacillus thuringiensis. Boehnisch C, et al. PLoS One, 2011. PMID 21931778, Free PMC Article
  3. Simple Evaluation of Listeria monocytogenes Pathogenesis Using Caenorhabditis elegans Animal Model. Yang KH, et al. Food Sci Anim Resour, 2019 Feb. PMID 30882077, Free PMC Article
  4. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. Irazoqui JE, et al. PLoS Pathog, 2010 Jul 1. PMID 20617181, Free PMC Article
  5. Diversification and adaptive sequence evolution of Caenorhabditis lysozymes (Nematoda: Rhabditidae). Schulenburg H, et al. BMC Evol Biol, 2008 Apr 19. PMID 18423043, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables lysozyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall macromolecule catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to Gram-positive bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Lysozyme-like protein 5
NP_502193.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11624252..11625582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069792.6 → NP_502193.1  Lysozyme-like protein 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502193.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20967
    Conserved Domains (1) summary
    cd06416
    Location:20 → 214
    GH25_Lys1-like; Lys-1 is a lysozyme encoded by the Caenorhabditis elegans lys-1 gene. This gene is one of a several lysozyme genes upregulated upon infection by the Gram-negative bacterial pathogen Serratia marcescens. Lys-1 contains a glycosyl hydrolase family 25 ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20967.1

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