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nhx-6 Sodium/hydrogen exchanger [ Caenorhabditis elegans ]

Gene ID: 186511, updated on 2-Nov-2024

Summary

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Official Symbol
nhx-6
Official Full Name
Sodium/hydrogen exchanger
Primary source
WormBase:WBGene00003734
Locus tag
CELE_F58E1.6
See related
AllianceGenome:WB:WBGene00003734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; congestive heart failure; and end stage renal disease. Orthologous to several human genes including SLC9A2 (solute carrier family 9 member A2); SLC9A3 (solute carrier family 9 member A3); and SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhx-6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (1670829..1674401)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Homeobox domain-containing protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene F-box associated domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A pair of RNA binding proteins inhibit ion transporter expression to maintain lifespan. Napier-Jameson R, et al. Genetics, 2024 Feb 7. PMID 38112749,
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sodium/hydrogen exchanger
NP_001022214.1
  • Partially confirmed by transcript evidence
NP_001022215.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    1670829..1674401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027044.4 → NP_001022215.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022215.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L039, Q8T5R6
    Conserved Domains (2) summary
    TIGR00840
    Location:43 → 551
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:104 → 456
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  2. NM_001027043.3 → NP_001022214.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022214.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T5R6, Q9TZH0
    Conserved Domains (1) summary
    pfam00999
    Location:104 → 456
    Na_H_Exchanger; Sodium/hydrogen exchanger family
Nucleotide Protein
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