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gpla-1 Bursicon [ Caenorhabditis elegans ]

Gene ID: 186548, updated on 2-Nov-2024

Summary

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Official Symbol
gpla-1
Official Full Name
Bursicon
Primary source
WormBase:WBGene00001466
Locus tag
CELE_F58H1.4
See related
AllianceGenome:WB:WBGene00001466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hormone receptor binding activity. Predicted to be involved in cell surface receptor signaling pathway. Located in extracellular space. Is expressed in neurons. Orthologous to human GPHA2 (glycoprotein hormone subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gpla-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (11936505..11937810, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Alpha-mannosidase Neighboring gene Secreted protein Neighboring gene Enolase-phosphatase E1 Neighboring gene Uncharacterized protein Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans. Take-Uchi M, et al. Proc Natl Acad Sci U S A, 1998 Sep 29. PMID 9751741, Free PMC Article
  2. FLR-2, the glycoprotein hormone alpha subunit, is involved in the neural control of intestinal functions in Caenorhabditis elegans. Oishi A, et al. Genes Cells, 2009 Oct. PMID 19735483
  3. Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans. Torzone SK, et al. PLoS Biol, 2023 Sep. PMID 37773960, Free PMC Article
  4. GPCR signaling regulates severe stress-induced organismic death in Caenorhabditis elegans. Wang C, et al. Aging Cell, 2023 Jan. PMID 36415159, Free PMC Article
  5. Ancestral glycoprotein hormone-receptor pathway controls growth in C. elegans. Kenis S, et al. Front Endocrinol (Lausanne), 2023. PMID 37409228, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Bursicon
NP_505998.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11936505..11937810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073597.3 → NP_505998.3  Bursicon [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8KHX6
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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