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rpa-4 RPA_C domain-containing protein;Replication protein A C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186576, updated on 2-Nov-2024

Summary

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Official Symbol
rpa-4
Official Full Name
RPA_C domain-containing protein;Replication protein A C-terminal domain-containing protein
Primary source
WormBase:WBGene00019079
Locus tag
CELE_F59A3.6
See related
AllianceGenome:WB:WBGene00019079
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Orthologous to human RPA2 (replication protein A2) and RPA4 (replication protein A4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpa-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
12
Sequence:
Chromosome: I; NC_003279.8 (5509470..5511689, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative MFS-type transporter C09D4.1 Neighboring gene Large ribosomal subunit protein uL24m Neighboring gene Zinc transporter ZIP11 Neighboring gene SPK domain-containing protein Neighboring gene MIF4G domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis. Hefel A, et al. Nucleic Acids Res, 2021 Feb 26. PMID 33476370, Free PMC Article
  2. DNA double-strand break repair in Caenorhabditis elegans. Lemmens BB, et al. Chromosoma, 2011 Feb. PMID 21052706, Free PMC Article
  3. R-loop-induced irreparable DNA damage evades checkpoint detection in the C. elegans germline. Hicks T, et al. Nucleic Acids Res, 2022 Aug 12. PMID 35871299, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis.
    Title: RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis.
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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA replication factor A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RPA_C domain-containing protein;Replication protein A C-terminal domain-containing protein
NP_001300421.1
  • Confirmed by transcript evidence
NP_001367475.1
  • Confirmed by transcript evidence
NP_001368496.1
  • Partially confirmed by transcript evidence
NP_001368500.1
  • Partially confirmed by transcript evidence
NP_001379644.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5509470..5511689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392313.1 → NP_001379644.1  RPA_C domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91356
    Conserved Domains (1) summary
    cd04478
    Location:64 → 162
    RPA2_DBD_D; A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...

  2. NM_001380260.1 → NP_001368496.1  Replication protein A C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I7G2
    Conserved Domains (1) summary
    cl09930
    Location:1 → 39
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

  3. NM_001380261.1 → NP_001368500.1  Replication protein A C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU77
    Conserved Domains (1) summary
    cl21533
    Location:71 → 111
    Cas8a1_I-A; CRISPR/Cas system-associated protein Cas8a1

  4. NM_001380262.1 → NP_001367475.1  Replication protein A C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I7G2
    Conserved Domains (1) summary
    cl09930
    Location:1 → 39
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

  5. NM_001313492.3 → NP_001300421.1  Replication protein A C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AU77

RNA

  1. NR_132558.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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