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Slc25a3 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 [ Mus musculus (house mouse) ]

Gene ID: 18674, updated on 3-Nov-2024

Summary

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Official Symbol
Slc25a3provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3provided by MGI
Primary source
MGI:MGI:1353498
See related
Ensembl:ENSMUSG00000061904 AllianceGenome:MGI:1353498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTP; Phc; 5730556H19Rik
Summary
Predicted to enable phosphate transmembrane transporter activity and phosphate:proton symporter activity. Predicted to be involved in phosphate ion transmembrane transport. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human SLC25A3 (solute carrier family 25 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 904.7), duodenum adult (RPKM 787.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc25a3 in Genome Data Viewer
Location:
10 C2; 10 45.6 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (90952436..90959902, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (91116574..91124046, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27538 Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene predicted gene, 25390 Neighboring gene STARR-positive B cell enhancer ABC_E9131 Neighboring gene IKBKB interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E370 Neighboring gene predicted gene, 24119 Neighboring gene STARR-positive B cell enhancer ABC_E6900 Neighboring gene thymopoietin Neighboring gene STARR-positive B cell enhancer ABC_E5165 Neighboring gene STARR-seq mESC enhancer starr_27543 Neighboring gene STARR-seq mESC enhancer starr_27545 Neighboring gene nuclear encoded tRNA aspartic acid 16 (anticodon GTC) Neighboring gene nuclear encoded tRNA trytophan 2 (anticodon CCA)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of glucocorticoid- and cyclic AMP-induced genes in T lymphocytes. Harrigan MT, et al. Mol Cell Biol, 1989 Aug. PMID 2552295, Free PMC Article
  2. An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD. Nakanishi T, et al. Exp Cell Res, 2023 Oct 1. PMID 37557977
  3. Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome. Peoples JN, et al. Am J Physiol Cell Physiol, 2021 Sep 1. PMID 34319827, Free PMC Article
  4. miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart. Baseler WA, et al. Am J Physiol Cell Physiol, 2012 Dec 15. PMID 23034391, Free PMC Article
  5. Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy. Kwong JQ, et al. Cell Death Differ, 2014 Aug. PMID 24658400, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
    Title: METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
  2. SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3.
    Title: SLC25A3 negatively regulates NLRP3 inflammasome activation by restricting the function of NLRP3.
  3. An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD.
    Title: An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD.
  4. Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome.
    Title: Loss of the mitochondrial phosphate carrier SLC25A3 induces remodeling of the cardiac mitochondrial protein acylome.
  5. SLC25A3 is a mitochondrial copper transporter.
    Title: The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis.
  6. The mitochondrial PiC is not a critical component of the MPT pore.
    Title: Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition.
  7. The results indicated that miR-141 can regulate Slc25a3 protein expression in the diabetic heart. Further, diabetes-induced miRNA changes may influence mitochondrial proteomes and functional processes such as mitochondrial ATP production.
    Title: miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphate:proton symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial phosphate ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 

General protein information

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Preferred Names
solute carrier family 25 member 3
Names
phosphate carrier protein, mitochondrial
phosphate transport protein
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428746.1 → NP_001415675.1  solute carrier family 25 member 3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC140410
    UniProtKB/TrEMBL
    G5E902

  2. NM_001428747.1 → NP_001415676.1  solute carrier family 25 member 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140410

  3. NM_133668.5 → NP_598429.1  solute carrier family 25 member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_598429.1

    Status: VALIDATED

    Source sequence(s)
    AC140410
    Consensus CDS
    CCDS24121.1
    UniProtKB/Swiss-Prot
    Q542V7, Q8VEM8
    UniProtKB/TrEMBL
    Q3THU8, Q3U995, Q3UB63
    Related
    ENSMUSP00000075987.7, ENSMUST00000076694.13
    Conserved Domains (2) summary
    PTZ00169
    Location:66 → 332
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:59 → 147
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_190487.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140410

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    90952436..90959902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513371.5 → XP_006513434.1  solute carrier family 25 member 3 isoform X1

    Related
    ENSMUSP00000127098.2, ENSMUST00000170810.8
    Conserved Domains (1) summary
    pfam00153
    Location:60 → 146
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEM8.1 GenPept UniProtKB/Swiss-Prot:Q8VEM8

Gene LinkOut

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