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otpl-8 Otopetrin-2 [ Caenorhabditis elegans ]

Gene ID: 186752, updated on 2-Nov-2024

Summary

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Official Symbol
otpl-8
Official Full Name
Otopetrin-2
Primary source
WormBase:WBGene00010403
Locus tag
CELE_H19J13.1
See related
AllianceGenome:WB:WBGene00010403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable proton channel activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human OTOP1 (otopetrin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See otpl-8 in Genome Data Viewer
Location:
chromosome: X
Exon count:
14
Sequence:
Chromosome: X; NC_003284.9 (12266953..12270941, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene Ovule protein Neighboring gene Ubiquitin-like domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members. Hughes I, et al. BMC Evol Biol, 2008 Feb 6. PMID 18254951, Free PMC Article
  2. An evolutionarily conserved gene family encodes proton-selective ion channels. Tu YH, et al. Science, 2018 Mar 2. PMID 29371428, Free PMC Article
  3. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hurle B, et al. Hum Mol Genet, 2003 Apr 1. PMID 12651873
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables proton channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton channel activity IEA
Inferred from Electronic Annotation
more info
  
enables proton channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Otopetrin-2
NP_510045.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    12266953..12270941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077644.6 → NP_510045.2  Otopetrin-2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDX5
    Conserved Domains (1) summary
    pfam03189
    Location:160 → 566
    Otopetrin; Otopetrin
Nucleotide Protein
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