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parg-2 Poly(ADP-ribose) glycohydrolase 2 [ Caenorhabditis elegans ]

Gene ID: 186765, updated on 2-Nov-2024

Summary

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Official Symbol
parg-2
Official Full Name
Poly(ADP-ribose) glycohydrolase 2
Primary source
WormBase:WBGene00004052
Locus tag
CELE_H23L24.5
See related
AllianceGenome:WB:WBGene00004052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables poly(ADP-ribose) glycohydrolase activity. Involved in nucleotide-sugar metabolic process and response to gamma radiation. Located in cytoplasm. Is expressed in head neurons and tail neurons. Orthologous to human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See parg-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (8712408..8715132, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Tubulin polyglutamylase ttll-11 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene PNPLA domain-containing protein Neighboring gene Phosphatidylinositol-glycan biosynthesis class X protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression. St-Laurent JF, et al. DNA Repair (Amst), 2007 Mar 1. PMID 17188026
  2. Poly(ADP-ribose) metabolism analysis in the nematode Caenorhabditis elegans. St-Laurent JF, et al. Methods Mol Biol, 2011. PMID 21870275
  3. The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. Gagnon SN, et al. Biochem J, 2002 Nov 15. PMID 12145714, Free PMC Article
  4. Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans. Bae W, et al. FEBS J, 2020 Mar. PMID 31593615
  5. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Boyd WA, et al. Mutat Res, 2010 Jan 5. PMID 19879883, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(ADP-ribose) glycohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(ADP-ribose) glycohydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(ADP-ribose) glycohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(ADP-ribose) glycohydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-sugar metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-sugar metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide-sugar metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Poly(ADP-ribose) glycohydrolase 2
NP_501496.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8712408..8715132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069095.5 → NP_501496.2  Poly(ADP-ribose) glycohydrolase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501496.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9N5L4
    Conserved Domains (1) summary
    pfam05028
    Location:116 → 435
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9N5L4.2

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