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sgcb-1 Beta-sarcoglycan [ Caenorhabditis elegans ]

Gene ID: 186816, updated on 2-Nov-2024

Summary

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Official Symbol
sgcb-1
Official Full Name
Beta-sarcoglycan
Primary source
WormBase:WBGene00019277
Locus tag
CELE_K01A2.1
See related
AllianceGenome:WB:WBGene00019277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in muscle organ development. Predicted to be located in membrane. Predicted to be part of sarcoglycan complex. Predicted to be active in sarcolemma. Is expressed in body wall musculature; enteric muscle; neurons; seam cell; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2E and muscular dystrophy. Orthologous to human SGCB (sarcoglycan beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sgcb-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (326300..328224)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Fatty Acid/Retinol binding protein Neighboring gene CCDC92 domain-containing protein;CCDC92/74 N-terminal domain-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic evidence for a dystrophin-glycoprotein complex (DGC) in Caenorhabditis elegans. Grisoni K, et al. Gene, 2002 Jul 10. PMID 12234669
  2. Identification of novel target genes of CeTwist and CeE/DA. Wang P, et al. Dev Biol, 2006 May 15. PMID 16480708
  3. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Berends CW, et al. Mol Biol Cell, 2013 Jul. PMID 23699393, Free PMC Article
  4. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of sarcoglycan complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sarcoglycan complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Beta-sarcoglycan
NP_493710.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    326300..328224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061309.6 → NP_493710.2  Beta-sarcoglycan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493710.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TZ49
    Conserved Domains (1) summary
    pfam04790
    Location:27 → 277
    Sarcoglycan_1; Sarcoglycan complex subunit protein
Nucleotide Protein
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