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grd-11 GRounDhog (hedgehog-like family) [ Caenorhabditis elegans ]

Gene ID: 186880, updated on 2-Nov-2024

Summary

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Official Symbol
grd-11
Official Full Name
GRounDhog (hedgehog-like family)
Primary source
WormBase:WBGene00001700
Locus tag
CELE_K02E2.2
See related
AllianceGenome:WB:WBGene00001700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in protein autoprocessing. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal (multiple); Hirschsprung's disease; bone development disease (multiple); holoprosencephaly (multiple); and hypoplastic or aplastic tibia with polydactyly. Orthologous to human IHH (Indian hedgehog signaling molecule); DHH (desert hedgehog signaling molecule); and SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See grd-11 in Genome Data Viewer
Location:
chromosome: V
Exon count:
15
Sequence:
Chromosome: V; NC_003283.11 (20356772..20365773)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Asn Neighboring gene Sodium-and chloride-dependent glycine transporter 2 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene DUF281 domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene pseudo Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans. Abete-Luzi P, et al. Genetics, 2020 Mar. PMID 31974205, Free PMC Article
  2. Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis. Aspöck G, et al. Genome Res, 1999 Oct. PMID 10523520
  3. Comprehensive analysis of gene expression patterns of hedgehog-related genes. Hao L, et al. BMC Genomics, 2006 Oct 31. PMID 17076889, Free PMC Article
  4. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Zugasti O, et al. Genome Res, 2005 Oct. PMID 16204193, Free PMC Article
  5. Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif. Bürglin TR. BMC Genomics, 2008 Mar 11. PMID 18334026, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GRounDhog (hedgehog-like family)
NP_507923.2
  • Product from WormBase gene class grd;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20356772..20365773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075522.4 → NP_507923.2  GRounDhog (hedgehog-like family) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507923.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUV2
    Conserved Domains (3) summary
    cd00081
    Location:758 → 920
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    pfam01079
    Location:758 → 974
    Hint; Hint module
    pfam04155
    Location:262 → 343
    Ground-like; Ground-like domain
Nucleotide Protein
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