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dos-3 Delta and OSM-11-like [ Caenorhabditis elegans ]

Gene ID: 186905, updated on 2-Nov-2024

Summary

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Official Symbol
dos-3
Official Full Name
Delta and OSM-11-like
Primary source
WormBase:WBGene00019331
Locus tag
CELE_K02F3.8
See related
AllianceGenome:WB:WBGene00019331
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Notch binding activity. Predicted to be involved in positive regulation of Notch signaling pathway. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dos-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (835751..839591, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transcription factor zip-2 Neighboring gene ncRNA Neighboring gene DUF148 domain-containing protein Neighboring gene Fatty Acid/Retinol binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells. Zhang Z, et al. Nat Commun, 2024 Jun 8. PMID 38851828, Free PMC Article
  2. Notch signaling inhibits axon regeneration. El Bejjani R, et al. Neuron, 2012 Jan 26. PMID 22284182, Free PMC Article
  3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells.
    Title: DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Delta and OSM-11-like
NP_497271.3
  • Product from WormBase gene class dos;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    835751..839591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064870.8 → NP_497271.3  Delta and OSM-11-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497271.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2MZA5
Nucleotide Protein
Heading Accession and Version

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