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aptf-1 Transcription factor aptf-1 [ Caenorhabditis elegans ]

Gene ID: 187043, updated on 2-Nov-2024

Summary

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Official Symbol
aptf-1
Official Full Name
Transcription factor aptf-1
Primary source
WormBase:WBGene00019424
Locus tag
CELE_K06A1.1
See related
AllianceGenome:WB:WBGene00019424
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and sleep. Predicted to be active in nucleus. Is expressed in head neurons and pharyngeal neurons. Human ortholog(s) of this gene implicated in Char syndrome; branchiooculofacial syndrome; and patent ductus arteriosus. Orthologous to several human genes including TFAP2C (transcription factor AP-2 gamma). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aptf-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
6
Sequence:
Chromosome: II; NC_003280.10 (6454971..6456546)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-22 Neighboring gene Autophagic-related protein 16.2 Neighboring gene Diacylglycerol kinase;Putative diacylglycerol kinase K06A1.6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Erratum: aptf-1 mutants are primarily defective in head movement quiescence during C. elegans sleep. . MicroPubl Biol, 2019 Aug 23. PMID 32550642, Free PMC Article
  2. An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans. Turek M, et al. Curr Biol, 2013 Nov 18. PMID 24184105
  3. Sleep-Active Neurons: Conserved Motors of Sleep. Bringmann H. Genetics, 2018 Apr. PMID 29618588, Free PMC Article
  4. aptf-1 mutants are primarily defective in head movement quiescence during C. elegans sleep. Robinson B, et al. MicroPubl Biol, 2019 Aug 19. PMID 32550461, Free PMC Article
  5. Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep. Turek M, et al. Elife, 2016 Mar 7. PMID 26949257, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aptf-1 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans.
    Title: An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transcription factor aptf-1
NP_495300.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    6454971..6456546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062899.4 → NP_495300.2  Transcription factor aptf-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495300.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09585
    Conserved Domains (1) summary
    pfam03299
    Location:152 → 355
    TF_AP-2; Transcription factor AP-2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09585.2

Gene LinkOut

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