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Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 18710, updated on 28-Oct-2024

Summary

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Official Symbol
Pik3r3provided by MGI
Official Full Name
phosphoinositide-3-kinase regulatory subunit 3provided by MGI
Primary source
MGI:MGI:109277
See related
Ensembl:ENSMUSG00000028698 Ensembl:ENSMUSG00000111410 AllianceGenome:MGI:109277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p55; p55pik
Summary
Enables 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within insulin receptor signaling pathway. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 19.3), CNS E14 (RPKM 19.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Pik3r3 in Genome Data Viewer
Location:
4 D1; 4 53.1 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116078593..116160253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116221400..116303056)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:115849369-115849478 Neighboring gene Pik3r3 upstream reading frame Neighboring gene STARR-seq mESC enhancer starr_11134 Neighboring gene STARR-seq mESC enhancer starr_11135 Neighboring gene LLP homolog, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E838 Neighboring gene STARR-seq mESC enhancer starr_11136 Neighboring gene BRCA1 associated RING domain 1 pseudogene Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene STARR-seq mESC enhancer starr_11138 Neighboring gene predicted gene, 52760 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116180277-116180386 Neighboring gene IAP promoted placental gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-κB pathway. Wang G, et al. Angiogenesis, 2013 Jul. PMID 23354733
  2. p55γ degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning. Li Z, et al. Cardiovasc Res, 2023 Nov 15. PMID 37527538
  3. Role of the p55-gamma subunit of PI3K in ALK-induced cell migration: RNAi-based selection of cell migration regulators. Seo M, et al. Cell Adh Migr, 2017 May 4. PMID 27322022, Free PMC Article
  4. VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas. Lee H, et al. J Clin Invest, 2024 Apr 15. PMID 38618953, Free PMC Article
  5. PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis. Yang X, et al. Exp Mol Med, 2018 Jan 19. PMID 29350678, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas.
    Title: VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas.
  2. p55gamma degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning.
    Title: p55γ degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning.
  3. PIK3R3 regulates the expression of PPAR-alpha.The activation of PIK3R3 decreased hepatosteatosis.The novel PIK3R3-HNF4alpha-PPAR-alpha signaling axis plays a significant role in hepatic lipid metabolism.
    Title: PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis.
  4. These data support an important role for the p55gamma subunit of PI3K in ALK-induced cell migration during brain development
    Title: Role of the p55-gamma subunit of PI3K in ALK-induced cell migration: RNAi-based selection of cell migration regulators.
  5. p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-kappaB pathway.
    Title: p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-κB pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-3-kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit gamma
Names
PI3-kinase regulatory subunit gamma
PI3-kinase subunit p55-gamma
PI3K regulatory subunit gamma
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
ptdIns-3-kinase regulatory subunit gamma
ptdIns-3-kinase regulatory subunit p55-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355584.2 → NP_001342513.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670603
    Consensus CDS
    CCDS18509.1
    UniProtKB/Swiss-Prot
    Q64143
    UniProtKB/TrEMBL
    Q3TST3, Q3UXE9
    Conserved Domains (3) summary
    cd09930
    Location:351 → 454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59 → 167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172 → 332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_001355585.2 → NP_001342514.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL670603
    Consensus CDS
    CCDS18509.1
    UniProtKB/Swiss-Prot
    Q64143
    UniProtKB/TrEMBL
    Q3TST3, Q3UXE9
    Conserved Domains (3) summary
    cd09930
    Location:351 → 454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59 → 167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172 → 332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  3. NM_001355586.2 → NP_001342515.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670603
    UniProtKB/TrEMBL
    Q3TST3
    Conserved Domains (3) summary
    cd09930
    Location:307 → 410
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:15 → 123
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:128 → 288
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  4. NM_001421303.1 → NP_001408232.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL670603

  5. NM_001421304.1 → NP_001408233.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL670603

  6. NM_001421305.1 → NP_001408234.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL670603

  7. NM_001421306.2 → NP_001408235.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL670603
    Related
    ENSMUSP00000150163.2, ENSMUST00000216692.2

  8. NM_001429908.1 → NP_001416837.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL670603

  9. NM_001429909.1 → NP_001416838.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL670603

  10. NM_001429910.1 → NP_001416839.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL670603

  11. NM_181585.7 → NP_853616.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

    See identical proteins and their annotated locations for NP_853616.1

    Status: VALIDATED

    Source sequence(s)
    AL670603
    Consensus CDS
    CCDS18509.1
    UniProtKB/Swiss-Prot
    Q64143
    UniProtKB/TrEMBL
    Q3TST3, Q3UXE9
    Related
    ENSMUSP00000030464.8, ENSMUST00000030464.14
    Conserved Domains (3) summary
    cd09930
    Location:351 → 454
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:59 → 167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172 → 332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116078593..116160253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502860.5 → XP_006502923.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_006502923.1

    UniProtKB/TrEMBL
    Q3TST3
    Conserved Domains (3) summary
    cd09942
    Location:59 → 167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172 → 332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    cl15255
    Location:351 → 396
    SH2; Src homology 2 (SH2) domain

  2. XM_006502859.4 → XP_006502922.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

    See identical proteins and their annotated locations for XP_006502922.1

    UniProtKB/TrEMBL
    Q3TST3
    Conserved Domains (3) summary
    cd09942
    Location:59 → 167
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:172 → 332
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    cl15255
    Location:351 → 396
    SH2; Src homology 2 (SH2) domain

  3. XM_030253316.2 → XP_030109176.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2

    Conserved Domains (3) summary
    cd09942
    Location:15 → 123
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cl25402
    Location:128 → 288
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    cl15255
    Location:307 → 352
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64143.1 GenPept UniProtKB/Swiss-Prot:Q64143

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