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pax-1 Paired box protein 1 homolog [ Caenorhabditis elegans ]

Gene ID: 187105, updated on 2-Nov-2024

Summary

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Official Symbol
pax-1
Official Full Name
Paired box protein 1 homolog
Primary source
WormBase:WBGene00003937
Locus tag
CELE_K07C11.1
See related
AllianceGenome:WB:WBGene00003937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to Gram-negative bacterium. Located in nucleus. Is expressed in epithelial cell and pharyngeal cell. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and tooth agenesis. Orthologous to several human genes including PAX9 (paired box 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pax-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (8224934..8226116)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Aurora kinase Neighboring gene ncRNA Neighboring gene BBSome-interacting protein 1 Neighboring gene ncRNA Neighboring gene Protein roller-3 Neighboring gene ncRNA Neighboring gene tRNA-Met

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA. Fakhouri TH, et al. PLoS Genet, 2010 Aug 12. PMID 20714352, Free PMC Article
  2. Pax genes in Caenorhabditis elegans: a new twist. Hobert O, et al. Trends Genet, 1999 Jun. PMID 10354580
  3. Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans. Sahu SN, et al. PLoS One, 2012. PMID 22675448, Free PMC Article
  4. Temporal regulation of foregut development by HTZ-1/H2A.Z and PHA-4/FoxA. Updike DL, et al. PLoS Genet, 2006 Sep 29. PMID 17009877, Free PMC Article
  5. In vitro and in vivo characterization of Caenorhabditis elegans PHA-4/FoxA response elements. Raharjo WH, et al. Dev Dyn, 2010 Aug. PMID 20623595

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Paired box protein 1 homolog
NP_505120.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8224934..8226116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072719.2 → NP_505120.1  Paired box protein 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505120.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21272
    Conserved Domains (1) summary
    smart00351
    Location:61 → 185
    PAX; Paired Box domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21272.1

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