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Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [ Mus musculus (house mouse) ]

Gene ID: 18718, updated on 2-Nov-2024

Summary

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Official Symbol
Pip4k2aprovided by MGI
Official Full Name
phosphatidylinositol-5-phosphate 4-kinase, type II, alphaprovided by MGI
Primary source
MGI:MGI:1298206
See related
Ensembl:ENSMUSG00000026737 AllianceGenome:MGI:1298206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pip5k2a
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; and protein homodimerization activity. Involved in autophagosome-lysosome fusion; megakaryocyte development; and regulation of autophagy. Located in lysosome. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and nose. Orthologous to human PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 11.5), cerebellum adult (RPKM 9.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Pip4k2a in Genome Data Viewer
Location:
2; 2 A3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (18847066..19003101, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (18842255..18998291, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 3363 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:18688736-18688845 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene cardiac and apoptosis-related long non-coding RNA Neighboring gene predicted gene, 33534 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:18845660-18845769 Neighboring gene RIKEN cDNA 4930426L09 gene Neighboring gene STARR-positive B cell enhancer ABC_E5892 Neighboring gene predicted gene, 33592

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition. Triscott J, et al. Sci Adv, 2023 Feb 3. PMID 36724278, Free PMC Article
  2. A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival. Jude JG, et al. Oncogene, 2015 Mar 5. PMID 24681948, Free PMC Article
  3. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Lundquist MR, et al. Mol Cell, 2018 May 3. PMID 29727621, Free PMC Article
  4. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Schulze H, et al. Blood, 2006 May 15. PMID 16434494, Free PMC Article
  5. A phosphoinositide conversion mechanism for exit from endosomes. Ketel K, et al. Nature, 2016 Jan 21. PMID 26760201

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AML cells, and for the clonogenic potential of murine MLL-AF9 AML cells.
    Title: A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in autophagosome-lysosome fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Names
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
PI(5)P 4-kinase type II alpha
PI5P4Kalpha
PIP4KII-alpha
diphosphoinositide kinase 2-alpha
phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
NP_001342075.1
NP_001342076.1
NP_001342077.1
NP_001342078.1
NP_032871.3
XP_006497457.1
XP_006497459.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355146.1 → NP_001342075.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL844855, AL928653, AL928680
    UniProtKB/TrEMBL
    Q9CZS7
    Conserved Domains (1) summary
    smart00330
    Location:62 → 392
    PIPKc; Phosphatidylinositol phosphate kinases

  2. NM_001355147.1 → NP_001342076.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL844855, AL928653, AL928680
    UniProtKB/TrEMBL
    Q9CZS7
    Conserved Domains (1) summary
    cl28923
    Location:27 → 352
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

  3. NM_001355148.1 → NP_001342077.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL844855, AL928653, AL928680
    Conserved Domains (1) summary
    cl02572
    Location:34 → 220
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

  4. NM_001355149.1 → NP_001342078.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) containss an alternate exon compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL844855, AL928653, AL928680
    Conserved Domains (1) summary
    cl28923
    Location:1 → 249
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

  5. NM_008845.4 → NP_032871.3  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 1

    See identical proteins and their annotated locations for NP_032871.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK040558, AL844855
    Consensus CDS
    CCDS15712.1
    UniProtKB/Swiss-Prot
    O70172
    UniProtKB/TrEMBL
    Q544E3, Q9CZS7
    Related
    ENSMUSP00000006912.6, ENSMUST00000006912.12
    Conserved Domains (1) summary
    smart00330
    Location:62 → 405
    PIPKc; Phosphatidylinositol phosphate kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    18847066..19003101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497396.5 → XP_006497459.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X2

    UniProtKB/TrEMBL
    Q9CZS7
    Conserved Domains (1) summary
    cl28923
    Location:27 → 341
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

  2. XM_006497394.5 → XP_006497457.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1

    UniProtKB/TrEMBL
    Q9CZS7
    Conserved Domains (1) summary
    cl28923
    Location:27 → 354
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70172.1 GenPept UniProtKB/Swiss-Prot:O70172

Gene LinkOut

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