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col-49 Cuticle collagen 49 [ Caenorhabditis elegans ]

Gene ID: 187239, updated on 2-Nov-2024

Summary

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Official Symbol
col-49
Official Full Name
Cuticle collagen 49
Primary source
WormBase:WBGene00000626
Locus tag
CELE_K09H9.3
See related
AllianceGenome:WB:WBGene00000626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cuticle. Involved in collagen and cuticulin-based cuticle development. Is expressed in hyp7 syncytium and seam cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See col-49 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003279.8 (3137185..3138447)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene DUF19 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of C. elegans L4 cuticle collagen genes by the heterochronic protein LIN-29. Abete-Luzi P, et al. Genesis, 2018 May. PMID 29604168, Free PMC Article
  2. Use of an activated beta-catenin to identify Wnt pathway target genes in caenorhabditis elegans, including a subset of collagen genes expressed in late larval development. Jackson BM, et al. G3 (Bethesda), 2014 Apr 16. PMID 24569038, Free PMC Article
  3. The adhesion GPCR and PCP component flamingo (FMI-1) alters body size and regulates the composition of the extracellular matrix. Schön JL, et al. Matrix Biol, 2024 Apr. PMID 38378098
  4. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans. Abete-Luzi P, et al. Genetics, 2020 Mar. PMID 31974205, Free PMC Article
  5. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen and cuticulin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Cuticle collagen 49
NP_491106.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3137185..3138447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058705.5 → NP_491106.1  Cuticle collagen 49 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491106.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44989
    Conserved Domains (2) summary
    pfam01391
    Location:186 → 243
    Collagen; Collagen triple helix repeat (20 copies)
    smart01088
    Location:4 → 56
    Col_cuticle_N; Nematode cuticle collagen N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44989.1

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