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pll-1 Phosphoinositide phospholipase C [ Caenorhabditis elegans ]

Gene ID: 187273, updated on 2-Nov-2024

Summary

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Official Symbol
pll-1
Official Full Name
Phosphoinositide phospholipase C
Primary source
WormBase:WBGene00004045
Locus tag
CELE_K10F12.3
See related
AllianceGenome:WB:WBGene00004045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway and regulation of GABAergic synaptic transmission. Is expressed in AIYL and AIYR. Orthologous to human PLCL1 (phospholipase C like 1 (inactive)) and PLCL2 (phospholipase C like 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pll-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
21
Sequence:
Chromosome: III; NC_003281.10 (365949..377570)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene PDZ domain-containing protein Neighboring gene BZIP domain-containing protein Neighboring gene ncRNA Neighboring gene GST N-terminal domain-containing protein;Glutathione-dependent dehydroascorbate reductase Neighboring gene Ovule protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inositol 1,4,5-trisphosphate signaling regulates mating behavior in Caenorhabditis elegans males. Gower NJ, et al. Mol Biol Cell, 2005 Sep. PMID 15958491, Free PMC Article
  2. Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma. Espelt MV, et al. J Gen Physiol, 2005 Oct. PMID 16186564, Free PMC Article
  3. Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans. Yin X, et al. Mol Biol Cell, 2004 Aug. PMID 15194811, Free PMC Article
  4. Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. Ziegler K, et al. Cell Host Microbe, 2009 Apr 23. PMID 19380113
  5. Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans. Wenick AS, et al. Dev Cell, 2004 Jun. PMID 15177025

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Phosphoinositide phospholipase C
NP_741067.1
  • Confirmed by transcript evidence
NP_741068.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    365949..377570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171059.6 → NP_741067.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741067.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IA76
    Conserved Domains (5) summary
    cd00275
    Location:680 → 808
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08558
    Location:357 → 653
    PI-PLCc_eukaryota; Catalytic domain of eukaryotic phosphoinositide-specific phospholipase C and similar proteins
    PLN02228
    Location:268 → 810
    PLN02228; Phosphoinositide phospholipase C
    cd13364
    Location:75 → 184
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam09279
    Location:276 → 356
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  2. NM_171060.5 → NP_741068.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IA75
    Conserved Domains (5) summary
    cd00275
    Location:687 → 815
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08558
    Location:364 → 660
    PI-PLCc_eukaryota; Catalytic domain of eukaryotic phosphoinositide-specific phospholipase C and similar proteins
    PLN02228
    Location:275 → 817
    PLN02228; Phosphoinositide phospholipase C
    cd13364
    Location:82 → 191
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam09279
    Location:283 → 363
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
Nucleotide Protein
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