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Pira6 paired-Ig-like receptor A6 [ Mus musculus (house mouse) ]

Gene ID: 18729, updated on 2-Nov-2024

Summary

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Official Symbol
Pira6provided by MGI
Official Full Name
paired-Ig-like receptor A6provided by MGI
Primary source
MGI:MGI:1195974
See related
AllianceGenome:MGI:1195974
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
12M1; p91B; Pira10
Summary
Predicted to be involved in negative regulation of osteoclast differentiation. Orthologous to human LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
not in current annotation release
Expression
Biased expression in spleen adult (RPKM 7.2), mammary gland adult (RPKM 3.7) and 14 other tissues See more
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Genomic context

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See Pira6 in Genome Data Viewer
Location:
7; 7 A1

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic structure of mouse PIR-A6, an activating member of the paired immunoglobulin-like receptor gene family. Tun T, et al. Tissue Antigens, 2003 Mar. PMID 12694571
  2. Genomic structures and chromosomal location of p91, a novel murine regulatory receptor family. Yamashita Y, et al. J Biochem, 1998 Feb. PMID 9538215
  3. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Kubagawa H, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144225, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
paired-Ig-like receptor A6
Names
killer cell inhibitory receptor-like protein p91B
paired-Ig-like receptor A10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289428.1 → NP_001276357.1  paired-Ig-like receptor A6 isoform c precursor

    See identical proteins and their annotated locations for NP_001276357.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AY216658
    UniProtKB/TrEMBL
    O70434
    Conserved Domains (2) summary
    smart00410
    Location:529 → 617
    IG_like; Immunoglobulin like
    cl11960
    Location:225 → 315
    Ig; Immunoglobulin domain

  2. NM_008848.1 → NP_032874.1  paired-Ig-like receptor A6 isoform a precursor

    See identical proteins and their annotated locations for NP_032874.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF041035
    UniProtKB/TrEMBL
    O55001, Q3ZB55
    Conserved Domains (2) summary
    smart00410
    Location:529 → 617
    IG_like; Immunoglobulin like
    cl11960
    Location:225 → 315
    Ig; Immunoglobulin domain

  3. NM_011093.1 → NP_035223.1  paired-Ig-like receptor A6 isoform b precursor

    See identical proteins and their annotated locations for NP_035223.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (b) lacks two internal segments, compared to isoform a.
    Source sequence(s)
    U96687
    UniProtKB/TrEMBL
    A2NTK3, D3Z674
    Conserved Domains (2) summary
    smart00410
    Location:430 → 518
    IG_like; Immunoglobulin like
    cl11960
    Location:225 → 315
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_019130.1: Suppressed sequence

    Description
    NG_019130.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

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