poml-1 PON (paraoxonase) and MEC-6 Like [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: poml-1
Official Full Name: PON (paraoxonase) and MEC-6 Like
Primary source: WormBase:WBGene00010775
Locus tag: CELE_K11E4.3
See related: AllianceGenome:WB:WBGene00010775
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein folding chaperone. Involved in protein maturation by protein folding. Located in rough endoplasmic reticulum. Is expressed in neurons. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); dementia (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1); PON2 (paraoxonase 2); and PON3 (paraoxonase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See poml-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (13719143..13722921, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEC-6 and POML-1 interact with MEC-4 to facilitate expression and localization of MEC-4 on the cell surface. Thus MEC-6 and POML-1 act more like chaperones for MEC-4 than channel components.
Title: Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K11E4.3 (e-PCR)
- UniSTS:313248

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables arylesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in protein maturation by protein folding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in rough endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PON (paraoxonase) and MEC-6 Like

NP_510296.2

Product from WormBase gene class poml;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13719143..13722921 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077895.4 → NP_510296.2 PON (paraoxonase) and MEC-6 Like [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510296.2

Status: REVIEWED

UniProtKB/TrEMBL

Q21427

Conserved Domains (1) summary

pfam01731
Location:158 → 243

Arylesterase; Arylesterase