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spe-49 Dendritic cell-specific transmembrane protein-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187315, updated on 2-Nov-2024

Summary

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Official Symbol
spe-49
Official Full Name
Dendritic cell-specific transmembrane protein-like domain-containing protein
Primary source
WormBase:WBGene00019667
Locus tag
CELE_K12B6.2
See related
AllianceGenome:WB:WBGene00019667
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in membrane. Is expressed in sperm. Orthologous to human DCST1 (DC-STAMP domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spe-49 in Genome Data Viewer
Location:
chromosome: V
Exon count:
17
Sequence:
Chromosome: V; NC_003283.11 (6281359..6284895)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Lipase Neighboring gene Conserved plasma membrane protein Neighboring gene G protein-coupled receptor Neighboring gene Secreted protein Neighboring gene Activin_recp domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans spe-49 gene is required for fertilization and encodes a sperm-specific transmembrane protein homologous to SPE-42. Wilson LD, et al. Mol Reprod Dev, 2018 Jul. PMID 29693775
  2. The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans. Krauchunas AR, et al. Curr Biol, 2023 Jul 24. PMID 37453426, Free PMC Article
  3. The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Cho S, et al. Curr Biol, 2007 Feb 6. PMID 17276913
  4. NHR-23 and SPE-44 regulate distinct sets of genes during Caenorhabditis elegans spermatogenesis. Ragle JM, et al. G3 (Bethesda), 2022 Nov 4. PMID 36135804, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caenorhabditis elegans spe-49 messenger RNA is enriched in male germ cells, and the complementary DNA encodes a predicted 772-amino-acid six-pass transmembrane protein that is homologous to SPE-42.
    Title: The Caenorhabditis elegans spe-49 gene is required for fertilization and encodes a sperm-specific transmembrane protein homologous to SPE-42.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dendritic cell-specific transmembrane protein-like domain-containing protein
NP_001343857.1
  • Partially confirmed by transcript evidence
NP_001343858.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6281359..6284895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356662.3 → NP_001343857.1  Dendritic cell-specific transmembrane protein-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C3Q9
    Conserved Domains (1) summary
    pfam07782
    Location:441 → 631
    DC_STAMP; DC-STAMP-like protein

  2. NM_001356661.4 → NP_001343858.1  Dendritic cell-specific transmembrane protein-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2C9C337
    Conserved Domains (1) summary
    pfam07782
    Location:441 → 631
    DC_STAMP; DC-STAMP-like protein
Nucleotide Protein
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