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trx-3 Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187389, updated on 2-Nov-2024

Summary

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Official Symbol
trx-3
Official Full Name
Thioredoxin domain-containing protein
Primary source
WormBase:WBGene00019717
Locus tag
CELE_M01H9.1
See related
AllianceGenome:WB:WBGene00019717
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in photoreceptor cell maintenance and sensory perception. Located in apical plasma membrane; cytoplasm; and nucleus. Is expressed in intestine. Orthologous to human NXNL2 (nucleoredoxin like 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See trx-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (4487028..4489000)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PhoLip_ATPase_C domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Gamma-aminobutyric acid type B receptor subunit 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein sleepless

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional characterization of thioredoxin 3 (TRX-3), a Caenorhabditis elegans intestine-specific thioredoxin. Jiménez-Hidalgo M, et al. Free Radic Biol Med, 2014 Mar. PMID 24316195, Free PMC Article
  2. The cytoplasmic thioredoxin system in Caenorhabditis elegans affords protection from methylmercury in an age-specific manner. Ruszkiewicz JA, et al. Neurotoxicology, 2018 Sep. PMID 30138651
  3. TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans. McCallum KC, et al. Genetics, 2016 May. PMID 26920757, Free PMC Article
  4. Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans. Romero-Afrima L, et al. Redox Biol, 2020 Jan. PMID 31677552, Free PMC Article
  5. The Redox System in C. elegans, a Phylogenetic Approach. Johnston AD, et al. J Toxicol, 2012. PMID 22899914, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in photoreceptor cell maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Thioredoxin domain-containing protein
NP_500578.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    4487028..4489000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068177.3 → NP_500578.2  Thioredoxin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500578.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q94282
    Conserved Domains (1) summary
    cd02964
    Location:11 → 132
    TryX_like_family; Tryparedoxin (TryX)-like family; composed of TryX and related proteins including nucleoredoxin (NRX), rod-derived cone viability factor (RdCVF) and the nematode homolog described as a 16-kD class of TRX. Most members of this family, except RdCVF, are ...
Nucleotide Protein
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