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tyra-3 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 187427, updated on 2-Nov-2024

Summary

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Official Symbol
tyra-3
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein
Primary source
WormBase:WBGene00006475
Locus tag
CELE_M03F4.3
See related
AllianceGenome:WB:WBGene00006475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable neurotransmitter receptor activity and octopamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to be located in membrane and synapse. Predicted to be active in dendrite and plasma membrane. Is expressed in intestine; nervous system; and reproductive system. Used to study Parkinson's disease. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tyra-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (4948049..4955358)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Actin;Actin-4 Neighboring gene EB domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Catecholamine receptor polymorphisms affect decision-making in C. elegans. Bendesky A, et al. Nature, 2011 Apr 21. PMID 21412235, Free PMC Article
  2. Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans. Hapiak V, et al. J Neurosci, 2013 Aug 28. PMID 23986246, Free PMC Article
  3. Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra-3/daf-11 signaling in Caenorhabditis elegans. Khanna A, et al. Aging Cell, 2021 May. PMID 33819374, Free PMC Article
  4. Coordination of behavioral hierarchies during environmental transitions in Caenorhabditis elegans. Vidal-Gadea AG, et al. Worm, 2012 Jan. PMID 23525841, Free PMC Article
  5. An oxytocin-dependent social interaction between larvae and adult C. elegans. Scott E, et al. Sci Rep, 2017 Aug 31. PMID 28860630, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled amine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables octopamine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to nitrogen compound IEA
Inferred from Electronic Annotation
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein
NP_001024804.1
  • Confirmed by transcript evidence
NP_001024805.1
  • Partially confirmed by transcript evidence
NP_001041275.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4948049..4955358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029633.5 → NP_001024804.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024804.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23013
    Conserved Domains (3) summary
    cd15061
    Location:73 → 272
    7tmA_tyramine_R-like; tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:460 → 490
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:458 → 536
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001029634.3 → NP_001024805.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024805.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JNP9
    Conserved Domains (3) summary
    cd15061
    Location:101 → 300
    7tmA_tyramine_R-like; tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:488 → 518
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:486 → 564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001047810.5 → NP_001041275.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041275.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2L6V9
    Conserved Domains (3) summary
    cd15061
    Location:1 → 193
    7tmA_tyramine_R-like; tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:381 → 411
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:379 → 457
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein
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