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gfl-1 YEATS domain-containing protein 4 [ Caenorhabditis elegans ]

Gene ID: 187434, updated on 2-Nov-2024

Summary

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Official Symbol
gfl-1
Official Full Name
YEATS domain-containing protein 4
Primary source
WormBase:WBGene00001585
Locus tag
CELE_M04B2.3
See related
AllianceGenome:WB:WBGene00001585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity and histone binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of NuA4 histone acetyltransferase complex. Predicted to be active in nucleus. Orthologous to human YEATS4 (YEATS domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gfl-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (11521290..11522214)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene FAD-dependent oxidoreductase domain-containing protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. Montgomery TA, et al. PLoS Genet, 2012. PMID 22536158, Free PMC Article
  2. Using RNA interference to identify genes required for RNA interference. Dudley NR, et al. Proc Natl Acad Sci U S A, 2002 Apr 2. PMID 11904378, Free PMC Article
  3. MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation. Phillips CM, et al. Curr Biol, 2014 Apr 14. PMID 24684932, Free PMC Article
  4. The Caenorhabditis elegans ekl (enhancer of ksr-1 lethality) genes include putative components of a germline small RNA pathway. Rocheleau CE, et al. Genetics, 2008 Mar. PMID 18245826, Free PMC Article
  5. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Wang D, et al. Nature, 2005 Jul 28. PMID 16049496

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
YEATS domain-containing protein 4
NP_502172.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11521290..11522214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069771.2 → NP_502172.1  YEATS domain-containing protein 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502172.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21501
    Conserved Domains (1) summary
    pfam03366
    Location:36 → 115
    YEATS; YEATS family
Nucleotide Protein
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