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pgap-3 Post-GPI attachment to proteins factor 3 [ Caenorhabditis elegans ]

Gene ID: 187504, updated on 2-Nov-2024

Summary

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Official Symbol
pgap-3
Official Full Name
Post-GPI attachment to proteins factor 3
Primary source
WormBase:WBGene00019806
Locus tag
CELE_R01B10.4
See related
AllianceGenome:WB:WBGene00019806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 4. Orthologous to human PGAP3 (post-GPI attachment to proteins phospholipase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pgap-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (6045640..6047918, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cystatin cpi-2 Neighboring gene Solute carrier family 3 member 2 N-terminal domain-containing protein Neighboring gene JNK1/MAPK8-associated membrane protein homolog Neighboring gene Seipin Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Post-GPI attachment to proteins factor 3
NP_504567.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6045640..6047918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072166.5 → NP_504567.1  Post-GPI attachment to proteins factor 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504567.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61975
    Conserved Domains (1) summary
    pfam04080
    Location:49 → 301
    Per1; Per1-like
Nucleotide Protein
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