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egg-2 LDL receptor repeat-containing protein egg-2 [ Caenorhabditis elegans ]

Gene ID: 187510, updated on 2-Nov-2024

Summary

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Official Symbol
egg-2
Official Full Name
LDL receptor repeat-containing protein egg-2
Primary source
WormBase:WBGene00019811
Locus tag
CELE_R01H2.3
See related
AllianceGenome:WB:WBGene00019811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable signaling receptor activity. Involved in eggshell formation; positive regulation of protein localization to cell periphery; and single fertilization. Located in plasma membrane. Is expressed in germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See egg-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (7058527..7060583, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Calsyntenin-1-like Neighboring gene Peptidase S1 domain-containing protein Neighboring gene DUF4806 domain-containing protein;SERPIN domain-containing protein Neighboring gene Ovule protein Neighboring gene GDP-L-fucose synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans. Kadandale P, et al. Curr Biol, 2005 Dec 20. PMID 16360684
  2. Eggshell chitin and chitin-interacting proteins prevent polyspermy in C. elegans. Johnston WL, et al. Curr Biol, 2010 Nov 9. PMID 20971008
  3. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans.
    Title: The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in eggshell formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein localization to cell cortex IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
  
involved_in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
LDL receptor repeat-containing protein egg-2
NP_498537.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7058527..7060583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066136.7 → NP_498537.1  LDL receptor repeat-containing protein egg-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498537.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21629
    Conserved Domains (1) summary
    cd00112
    Location:300 → 327
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21629.1

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