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nuaf-3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [ Caenorhabditis elegans ]

Gene ID: 187686, updated on 2-Nov-2024

Summary

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Official Symbol
nuaf-3
Official Full Name
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
Primary source
WormBase:WBGene00011123
Locus tag
CELE_R07H5.3
See related
AllianceGenome:WB:WBGene00011123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 18. Orthologous to human NDUFAF3 (NADH:ubiquinone oxidoreductase complex assembly factor 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nuaf-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (11184291..11186012)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RAP homolog (vertebrate Rap GTPase family) Neighboring gene Uncharacterized protein Neighboring gene Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein Neighboring gene Peroxisomal membrane protein PEX14 Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene F-box associated domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans. Chuaijit S, et al. Mitochondrion, 2019 May. PMID 29540318
  2. Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegans. van den Ecker D, et al. Mitochondrion, 2012 May. PMID 22387847
  3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We demonstrate that two candidates (C50B8.3/NUAF-1, homologue of NDUFAF1 and R07H5.3/NUAF-3, homologue of NDUFAF3) clearly affect complex I function.
    Title: Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
NP_001023328.1
  • Confirmed by transcript evidence
NP_001129864.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11184291..11186012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028157.5 → NP_001023328.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023328.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93931
    Conserved Domains (1) summary
    cd05125
    Location:72 → 186
    Mth938_2P1-like; Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the ...

  2. NM_001136392.4 → NP_001129864.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129864.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2MZC3
    Conserved Domains (1) summary
    cd05125
    Location:22 → 136
    Mth938_2P1-like; Mth938_2P1-like domain. This model contains sequences that are similar to 2P1, a partially characterized nuclear protein, which is homologous to E3-3 from rat and known to be alternatively spliced. Its function is unknown. This family is part of the ...
Nucleotide Protein
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